Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1972356..1972984 Replicon chromosome
Accession NZ_CP035810
Organism Brevibacterium luteolum strain NEB1784

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EW640_RS09085 Protein ID WP_165883819.1
Coordinates 1972356..1972775 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EW640_RS09090 Protein ID WP_207948859.1
Coordinates 1972766..1972984 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW640_RS09055 1967494..1968051 + 558 WP_165883814.1 hypothetical protein -
EW640_RS09060 1968101..1968502 + 402 WP_102163096.1 helix-turn-helix domain-containing protein -
EW640_RS09065 1968499..1969071 + 573 WP_165883815.1 PIN domain-containing protein -
EW640_RS09070 1969290..1970465 - 1176 WP_165883816.1 MFS transporter -
EW640_RS09075 1970521..1970811 - 291 WP_165883817.1 helix-turn-helix domain-containing protein -
EW640_RS09080 1971028..1972251 + 1224 WP_165883818.1 MFS transporter -
EW640_RS09085 1972356..1972775 - 420 WP_165883819.1 PIN domain nuclease Toxin
EW640_RS09090 1972766..1972984 - 219 WP_207948859.1 hypothetical protein Antitoxin
EW640_RS09095 1973072..1974199 - 1128 WP_165883821.1 serine hydrolase -
EW640_RS09100 1974183..1976078 - 1896 WP_165883822.1 ABC transporter ATP-binding protein -
EW640_RS09105 1976075..1977049 - 975 WP_165883823.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.77 Da        Isoelectric Point: 4.5732

>T118542 WP_165883819.1 NZ_CP035810:c1972775-1972356 [Brevibacterium luteolum]
MAMTSWLIDTSAFVRLQLGQASDSGIWNARIERGLVRISTITRLEVGFSVRAGEAGRMIFAEPPLSLMPIEYLTPAMEDR
AWEVQMLLADRGQHRAPSIPDLLIAATAEKLGLTVLAVDKDFDLIAELTGQPVETLTLR

Download         Length: 420 bp

>T118542 NZ_CP035810:c1972775-1972356 [Brevibacterium luteolum]
ATGGCGATGACGAGCTGGCTCATCGACACGTCCGCGTTCGTGCGGTTGCAGCTGGGGCAGGCGTCAGATTCTGGGATCTG
GAACGCGCGGATCGAGCGCGGTCTCGTCCGGATATCGACGATCACCCGGCTCGAGGTCGGTTTCTCGGTGCGTGCCGGTG
AAGCCGGGCGGATGATCTTCGCCGAGCCTCCGCTGTCGCTGATGCCGATCGAGTACCTGACGCCTGCGATGGAGGATCGT
GCCTGGGAGGTGCAGATGCTGCTGGCAGACCGTGGCCAGCATCGTGCGCCGTCCATCCCAGATCTTCTCATCGCCGCAAC
TGCCGAGAAGCTGGGCCTGACTGTGCTGGCCGTGGACAAGGACTTCGACCTGATCGCGGAGCTGACGGGACAGCCGGTGG
AGACGCTCACGCTGCGTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8225.18 Da        Isoelectric Point: 4.6437

>AT118542 WP_207948859.1 NZ_CP035810:c1972984-1972766 [Brevibacterium luteolum]
MNVLIRGLSDEAVARIDRSAEELGLSRNEYLRRRLEGDDSRPAVKLTDEHWKRSAEVLADLADSDIMADAWR

Download         Length: 219 bp

>AT118542 NZ_CP035810:c1972984-1972766 [Brevibacterium luteolum]
ATGAATGTGCTGATTCGTGGACTCAGCGATGAGGCTGTCGCTCGAATCGACAGGAGTGCTGAAGAGCTGGGCCTTTCGCG
CAATGAATACCTCCGGCGCAGGCTTGAGGGTGATGACTCCCGCCCGGCGGTCAAACTCACTGACGAGCATTGGAAGCGGT
CGGCCGAGGTTCTTGCCGACCTCGCCGATTCCGACATCATGGCCGACGCATGGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References