Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1205600..1206255 Replicon chromosome
Accession NZ_CP035810
Organism Brevibacterium luteolum strain NEB1784

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EW640_RS05535 Protein ID WP_165883255.1
Coordinates 1205600..1206025 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EW640_RS05540 Protein ID WP_165883256.1
Coordinates 1206022..1206255 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW640_RS05510 1201318..1201584 + 267 WP_165883250.1 hypothetical protein -
EW640_RS05515 1201773..1202213 - 441 WP_165883251.1 YtoQ family protein -
EW640_RS05520 1202382..1203383 - 1002 WP_165883252.1 IS481 family transposase -
EW640_RS05525 1203528..1204352 - 825 WP_165883253.1 alpha/beta hydrolase -
EW640_RS05530 1204408..1205187 - 780 WP_165883254.1 biotin--protein ligase -
EW640_RS05535 1205600..1206025 - 426 WP_165883255.1 type II toxin-antitoxin system VapC family toxin Toxin
EW640_RS05540 1206022..1206255 - 234 WP_165883256.1 Arc family DNA-binding protein Antitoxin
EW640_RS05545 1206448..1207398 - 951 WP_165883257.1 IS3 family transposase -
EW640_RS05550 1207395..1207712 - 318 WP_010080477.1 helix-turn-helix domain-containing protein -
EW640_RS05555 1207841..1208017 + 177 Protein_1080 integrase core domain-containing protein -
EW640_RS05560 1208296..1209365 + 1070 Protein_1081 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1191652..1207446 15794
- flank IS/Tn - - 1202382..1203383 1001


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin

Arc-like DNA binding domain

(11-40)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15011.99 Da        Isoelectric Point: 4.5849

>T118541 WP_165883255.1 NZ_CP035810:c1206025-1205600 [Brevibacterium luteolum]
MIVLDTNVISEIFRPSPEPRVIEWLVSLTGDVAITSITLAELLAGVRSLPDGRRKDDLAQRIEQAVAPYRGSRSVLAFDA
DAAERYAEVLASREAAGAPVSTADAQIAAICLAHGATCATRNVKDFQHTGVELVGPWNADA

Download         Length: 426 bp

>T118541 NZ_CP035810:c1206025-1205600 [Brevibacterium luteolum]
ATGATCGTGCTCGACACGAACGTCATCTCGGAGATCTTTCGGCCCTCGCCGGAGCCTCGTGTCATCGAGTGGCTCGTGTC
CCTGACGGGCGACGTCGCGATCACGTCGATTACTCTCGCGGAGTTGCTTGCCGGTGTGCGCAGCCTCCCGGACGGCCGAC
GCAAAGACGATCTGGCTCAGAGGATCGAACAAGCAGTAGCGCCGTATCGGGGCAGCCGGTCGGTGCTCGCATTCGATGCT
GACGCGGCGGAGCGATACGCGGAGGTGCTCGCGTCGCGCGAGGCAGCAGGTGCGCCTGTCAGTACGGCCGACGCCCAGAT
CGCCGCGATCTGCCTGGCGCACGGGGCAACCTGCGCTACACGCAACGTGAAAGATTTCCAGCACACCGGCGTCGAACTCG
TGGGCCCGTGGAATGCGGACGCGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8308.55 Da        Isoelectric Point: 8.8756

>AT118541 WP_165883256.1 NZ_CP035810:c1206255-1206022 [Brevibacterium luteolum]
MSSIIVRGLDDGVKQQLAAQAKEHGRSMEAEVRDILTKAARRPHIGMALLSVARQVGGVGELKIPTRDDVARAADFE

Download         Length: 234 bp

>AT118541 NZ_CP035810:c1206255-1206022 [Brevibacterium luteolum]
ATGTCATCCATCATTGTCCGTGGCCTCGATGACGGCGTGAAGCAGCAGCTTGCCGCACAGGCCAAGGAGCACGGGCGGTC
CATGGAGGCCGAGGTTCGCGACATCCTGACGAAGGCCGCCCGACGGCCGCACATTGGCATGGCTCTGCTGTCCGTGGCGC
GGCAAGTCGGTGGGGTTGGTGAGTTGAAGATTCCGACGCGCGATGACGTCGCAAGGGCGGCGGACTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References