Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1205600..1206255 Replicon chromosome
Accession NZ_CP035810
Organism Brevibacterium luteolum strain NEB1784

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EW640_RS05535 Protein ID WP_165883255.1
Coordinates 1205600..1206025 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EW640_RS05540 Protein ID WP_165883256.1
Coordinates 1206022..1206255 (-) Length 78 a.a.

Genomic Context

EW640_RS05510EW640_RS05555EW640_RS05560EW640_RS05515EW640_RS05520EW640_RS05525EW640_RS05530EW640_RS05535EW640_RS05540EW640_RS05545EW640_RS05550
Location: 1201318..1201584 (267 bp)
Type: Others
Protein ID: WP_165883250.1
Location: 1207841..1208017 (177 bp)
Type: Others
Protein ID: Protein_1080
Location: 1208296..1209365 (1070 bp)
Type: Others
Protein ID: Protein_1081
Location: 1201773..1202213 (441 bp)
Type: Others
Protein ID: WP_165883251.1
Location: 1202382..1203383 (1002 bp)
Type: Others
Protein ID: WP_165883252.1
Location: 1203528..1204352 (825 bp)
Type: Others
Protein ID: WP_165883253.1
Location: 1204408..1205187 (780 bp)
Type: Others
Protein ID: WP_165883254.1
Location: 1205600..1206025 (426 bp)
Type: Toxin
Protein ID: WP_165883255.1
Location: 1206022..1206255 (234 bp)
Type: Antitoxin
Protein ID: WP_165883256.1
Location: 1206448..1207398 (951 bp)
Type: Others
Protein ID: WP_165883257.1
Location: 1207395..1207712 (318 bp)
Type: Others
Protein ID: WP_010080477.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EW640_RS055101201318..1201584+267WP_165883250.1hypothetical protein-
EW640_RS055151201773..1202213-441WP_165883251.1YtoQ family protein-
EW640_RS055201202382..1203383-1002WP_165883252.1IS481 family transposase-
EW640_RS055251203528..1204352-825WP_165883253.1alpha/beta hydrolase-
EW640_RS055301204408..1205187-780WP_165883254.1biotin--protein ligase-
EW640_RS055351205600..1206025-426WP_165883255.1type II toxin-antitoxin system VapC family toxinToxin
EW640_RS055401206022..1206255-234WP_165883256.1Arc family DNA-binding proteinAntitoxin
EW640_RS055451206448..1207398-951WP_165883257.1IS3 family transposase-
EW640_RS055501207395..1207712-318WP_010080477.1helix-turn-helix domain-containing protein-
EW640_RS055551207841..1208017+177Protein_1080integrase core domain-containing protein-
EW640_RS055601208296..1209365+1070Protein_1081IS110 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1191652..120744615794
-flankIS/Tn--1202382..12033831001


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin

Arc-like DNA binding domain

(11-40)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15011.99 Da        Isoelectric Point: 4.5849

>T118541 WP_165883255.1 NZ_CP035810:c1206025-1205600 [Brevibacterium luteolum]
MIVLDTNVISEIFRPSPEPRVIEWLVSLTGDVAITSITLAELLAGVRSLPDGRRKDDLAQRIEQAVAPYRGSRSVLAFDA
DAAERYAEVLASREAAGAPVSTADAQIAAICLAHGATCATRNVKDFQHTGVELVGPWNADA

Download         Length: 426 bp

>T118541 NZ_CP035810:c1206025-1205600 [Brevibacterium luteolum]
ATGATCGTGCTCGACACGAACGTCATCTCGGAGATCTTTCGGCCCTCGCCGGAGCCTCGTGTCATCGAGTGGCTCGTGTC
CCTGACGGGCGACGTCGCGATCACGTCGATTACTCTCGCGGAGTTGCTTGCCGGTGTGCGCAGCCTCCCGGACGGCCGAC
GCAAAGACGATCTGGCTCAGAGGATCGAACAAGCAGTAGCGCCGTATCGGGGCAGCCGGTCGGTGCTCGCATTCGATGCT
GACGCGGCGGAGCGATACGCGGAGGTGCTCGCGTCGCGCGAGGCAGCAGGTGCGCCTGTCAGTACGGCCGACGCCCAGAT
CGCCGCGATCTGCCTGGCGCACGGGGCAACCTGCGCTACACGCAACGTGAAAGATTTCCAGCACACCGGCGTCGAACTCG
TGGGCCCGTGGAATGCGGACGCGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8308.55 Da        Isoelectric Point: 8.8756

>AT118541 WP_165883256.1 NZ_CP035810:c1206255-1206022 [Brevibacterium luteolum]
MSSIIVRGLDDGVKQQLAAQAKEHGRSMEAEVRDILTKAARRPHIGMALLSVARQVGGVGELKIPTRDDVARAADFE

Download         Length: 234 bp

>AT118541 NZ_CP035810:c1206255-1206022 [Brevibacterium luteolum]
ATGTCATCCATCATTGTCCGTGGCCTCGATGACGGCGTGAAGCAGCAGCTTGCCGCACAGGCCAAGGAGCACGGGCGGTC
CATGGAGGCCGAGGTTCGCGACATCCTGACGAAGGCCGCCCGACGGCCGCACATTGGCATGGCTCTGCTGTCCGTGGCGC
GGCAAGTCGGTGGGGTTGGTGAGTTGAAGATTCCGACGCGCGATGACGTCGCAAGGGCGGCGGACTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References