Detailed information of TA system TA118538

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2636604..2637235
• Replicon: chromosome
• Accession: NZ_CP035807
• Organism: Thiospirochaeta perfilievii strain P

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: EW093_RS12150
• Protein ID: WP_149568671.1
• Coordinates: 2636834..2637235 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: EW093_RS12145
• Protein ID: WP_149568670.1
• Coordinates: 2636604..2636834 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EW093_RS12125	2632871..2633839	+	969	WP_149568666.1	hypothetical protein	-
EW093_RS12130	2633902..2634510	+	609	WP_149568667.1	hypothetical protein	-
EW093_RS12135	2634572..2635468	+	897	WP_149568668.1	GNAT family N-acetyltransferase	-
EW093_RS12140	2635465..2636349	-	885	WP_149568669.1	1-acyl-sn-glycerol-3-phosphate acyltransferase	-
EW093_RS12145	2636604..2636834	+	231	WP_149568670.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
EW093_RS12150	2636834..2637235	+	402	WP_149568671.1	type II toxin-antitoxin system VapC family toxin	Toxin
EW093_RS12155	2637288..2637929	-	642	WP_149568672.1	HAD hydrolase-like protein	-
EW093_RS12160	2637938..2638648	-	711	WP_149568673.1	hypothetical protein	-
EW093_RS12165	2638740..2641757	+	3018	WP_149568674.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

• SpoVT-AbrB domain (9-49)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15073.52 Da
• Isoelectric Point: 6.3288

>T118538 WP_149568671.1 NZ_CP035807:2636834-2637235 [Thiospirochaeta perfilievii]
MYLLDTNICIYAIKNKPKSVLKKISENFNNGIYISSLTIAELEFGVSNSQNPENNRISLLEFLAIFTVLPFNEKDAIPYG
KIKTYLRKSGNIIGPIDMLLSAQAISNDLIFITNNTKEFIRVPDIKLEDWSLV

Nucleotide

• Length: 402 bp

>T118538 NZ_CP035807:2636834-2637235 [Thiospirochaeta perfilievii]
ATGTACTTACTTGATACCAATATTTGTATTTATGCTATTAAAAATAAACCTAAGAGTGTTTTAAAAAAGATATCAGAAAA
TTTTAACAATGGGATTTATATCTCATCTCTAACTATAGCAGAGTTAGAGTTCGGTGTTTCTAATAGTCAAAATCCTGAGA
ATAATAGAATTTCACTCCTTGAGTTTTTAGCAATATTTACTGTTTTACCATTTAATGAAAAAGATGCCATTCCTTATGGA
AAAATCAAAACATACTTAAGAAAATCTGGAAATATTATTGGTCCTATTGATATGCTTTTATCTGCTCAGGCTATTTCAAA
TGACTTGATTTTTATTACAAATAATACAAAGGAATTTATCCGAGTCCCTGATATTAAGCTTGAAGACTGGTCTCTTGTGT
AA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8861.77 Da
• Isoelectric Point: 4.5679

>AT118538 WP_149568670.1 NZ_CP035807:2636604-2636834 [Thiospirochaeta perfilievii]
MQTAKLFANGRSQAVRLPKEYQFQGEDVFIQKHGDAVILMPHDKAWETFIHGLNSFTDDFMEDGREQGQNQDREDF

Nucleotide

• Length: 231 bp

>AT118538 NZ_CP035807:2636604-2636834 [Thiospirochaeta perfilievii]
ATGCAAACAGCGAAATTATTTGCCAATGGAAGAAGTCAAGCAGTAAGACTCCCTAAAGAATATCAGTTTCAGGGAGAAGA
TGTATTTATACAAAAACATGGGGATGCAGTTATTTTAATGCCACATGATAAGGCATGGGAAACTTTCATACATGGTTTAA
ACTCTTTTACTGATGATTTTATGGAAGATGGAAGAGAGCAGGGGCAGAATCAGGATAGAGAAGATTTTTAA