Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 1410387..1410892 Replicon chromosome
Accession NZ_CP035807
Organism Thiospirochaeta perfilievii strain P

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EW093_RS06450 Protein ID WP_149567603.1
Coordinates 1410638..1410892 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EW093_RS06445 Protein ID WP_149567602.1
Coordinates 1410387..1410641 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW093_RS06395 1405821..1406098 + 278 Protein_1263 BrnT family toxin -
EW093_RS06400 1406103..1406318 + 216 WP_149567595.1 BrnA antitoxin family protein -
EW093_RS06405 1406449..1406634 + 186 WP_149567596.1 hypothetical protein -
EW093_RS06410 1406622..1406912 + 291 WP_149567597.1 type II toxin-antitoxin system RelE/ParE family toxin -
EW093_RS06415 1407063..1407311 + 249 WP_149567598.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
EW093_RS06420 1407305..1407628 + 324 WP_149569586.1 type II toxin-antitoxin system PemK/MazF family toxin -
EW093_RS06425 1407822..1408103 + 282 Protein_1269 type II toxin-antitoxin system RelE/ParE family toxin -
EW093_RS06430 1408113..1408412 + 300 WP_149567599.1 HigA family addiction module antidote protein -
EW093_RS06435 1408561..1409718 - 1158 WP_149567600.1 IS4 family transposase -
EW093_RS06440 1409851..1410168 + 318 WP_149567601.1 outer membrane protein assembly factor BamE -
EW093_RS06445 1410387..1410641 + 255 WP_149567602.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
EW093_RS06450 1410638..1410892 + 255 WP_149567603.1 Txe/YoeB family addiction module toxin Toxin
EW093_RS17285 1411102..1411275 + 174 WP_187759859.1 hypothetical protein -
EW093_RS06455 1411275..1411565 + 291 Protein_1276 type II toxin-antitoxin system RelE/ParE family toxin -
EW093_RS17290 1411690..1411866 + 177 WP_187759860.1 hypothetical protein -
EW093_RS06460 1411860..1412141 + 282 WP_149567604.1 type II toxin-antitoxin system RelE/ParE family toxin -
EW093_RS06465 1412279..1413127 + 849 WP_149567605.1 hypothetical protein -
EW093_RS06470 1413480..1413773 + 294 WP_149567606.1 hypothetical protein -
EW093_RS06475 1413809..1414138 + 330 WP_149567607.1 type II toxin-antitoxin system PemK/MazF family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10206.84 Da        Isoelectric Point: 8.7033

>T118536 WP_149567603.1 NZ_CP035807:1410638-1410892 [Thiospirochaeta perfilievii]
MNITFTSDSWDDYLYWQKNDKKIIKRINELIKEIKRCPFEGIGKPEPLKFQLQGCWSRRIDQEHRIVYEVADKSILIIGC
RFHY

Download         Length: 255 bp

>T118536 NZ_CP035807:1410638-1410892 [Thiospirochaeta perfilievii]
ATGAACATAACATTTACATCTGATTCTTGGGATGATTATCTTTACTGGCAAAAAAATGATAAGAAAATAATAAAAAGAAT
TAATGAACTTATTAAAGAAATTAAAAGATGTCCTTTTGAGGGGATTGGAAAACCAGAACCTTTAAAATTCCAACTCCAGG
GCTGTTGGTCAAGAAGAATTGATCAAGAGCACAGAATAGTTTACGAAGTAGCTGATAAATCGATTTTAATTATTGGTTGT
AGGTTCCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9744.76 Da        Isoelectric Point: 4.7164

>AT118536 WP_149567602.1 NZ_CP035807:1410387-1410641 [Thiospirochaeta perfilievii]
MNAVNYTDLRQNLKSHMDSVYQDHEPLIVTRKDNQNVVLISLEDYNSLTETQYLLSSQNNANRLLRSLSDARNGNTFTKE
LIEE

Download         Length: 255 bp

>AT118536 NZ_CP035807:1410387-1410641 [Thiospirochaeta perfilievii]
ATGAATGCAGTTAATTACACCGATTTACGCCAGAATTTAAAATCTCACATGGACAGCGTCTATCAAGATCATGAACCTCT
TATTGTTACTAGAAAAGACAACCAGAATGTTGTTTTAATTTCTTTAGAAGATTATAACAGTTTAACTGAAACTCAGTATT
TATTATCTTCTCAAAACAACGCAAACAGATTGTTAAGATCATTATCTGATGCAAGAAATGGAAATACTTTTACAAAAGAA
CTTATTGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References