Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazE-MazF
Location 1407063..1407628 Replicon chromosome
Accession NZ_CP035807
Organism Thiospirochaeta perfilievii strain P

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EW093_RS06415 Protein ID WP_149567598.1
Coordinates 1407063..1407311 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EW093_RS06420 Protein ID WP_149569586.1
Coordinates 1407305..1407628 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW093_RS06380 1403039..1403878 + 840 WP_149567592.1 tyrosine-type recombinase/integrase -
EW093_RS06385 1403832..1404095 + 264 WP_149567593.1 transposase zinc-binding domain-containing protein -
EW093_RS06390 1404065..1405030 + 966 WP_187759857.1 transposase -
EW093_RS17280 1405364..1405603 + 240 WP_187759858.1 hypothetical protein -
EW093_RS06395 1405821..1406098 + 278 Protein_1263 BrnT family toxin -
EW093_RS06400 1406103..1406318 + 216 WP_149567595.1 BrnA antitoxin family protein -
EW093_RS06405 1406449..1406634 + 186 WP_149567596.1 hypothetical protein -
EW093_RS06410 1406622..1406912 + 291 WP_149567597.1 type II toxin-antitoxin system RelE/ParE family toxin -
EW093_RS06415 1407063..1407311 + 249 WP_149567598.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
EW093_RS06420 1407305..1407628 + 324 WP_149569586.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
EW093_RS06425 1407822..1408103 + 282 Protein_1269 type II toxin-antitoxin system RelE/ParE family toxin -
EW093_RS06430 1408113..1408412 + 300 WP_149567599.1 HigA family addiction module antidote protein -
EW093_RS06435 1408561..1409718 - 1158 WP_149567600.1 IS4 family transposase -
EW093_RS06440 1409851..1410168 + 318 WP_149567601.1 outer membrane protein assembly factor BamE -
EW093_RS06445 1410387..1410641 + 255 WP_149567602.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
EW093_RS06450 1410638..1410892 + 255 WP_149567603.1 Txe/YoeB family addiction module toxin -
EW093_RS17285 1411102..1411275 + 174 WP_187759859.1 hypothetical protein -
EW093_RS06455 1411275..1411565 + 291 Protein_1276 type II toxin-antitoxin system RelE/ParE family toxin -
EW093_RS17290 1411690..1411866 + 177 WP_187759860.1 hypothetical protein -
EW093_RS06460 1411860..1412141 + 282 WP_149567604.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

mRNA interferase PemK-like

(5-105)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9520.86 Da        Isoelectric Point: 4.4901

>T118534 WP_149567598.1 NZ_CP035807:1407063-1407311 [Thiospirochaeta perfilievii]
MQISVIPIGNSKGIRIPKNILTQLHIEDSVELEVHNKEILIKPIHKNVREGWTTAFKSMSVNNEDDLLIPDNMDLEESEW
EW

Download         Length: 249 bp

>T118534 NZ_CP035807:1407063-1407311 [Thiospirochaeta perfilievii]
ATGCAGATATCAGTAATACCAATAGGTAACTCAAAAGGTATAAGAATCCCTAAAAATATACTTACTCAATTACACATAGA
AGATTCTGTAGAACTTGAAGTTCATAACAAAGAGATATTAATAAAACCTATTCATAAGAATGTAAGAGAAGGTTGGACAA
CAGCATTTAAAAGCATGTCAGTAAATAATGAAGATGATTTATTAATTCCAGATAATATGGATTTAGAGGAATCTGAGTGG
GAATGGTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12309.57 Da        Isoelectric Point: 10.0717

>AT118534 WP_149569586.1 NZ_CP035807:1407305-1407628 [Thiospirochaeta perfilievii]
MVINQYDILLVNLDHTVGHEIQKTRPCVVISPDEMNHSIKTVIISPMTTKSHNYPTRISITFEKKDGWVVLDQIRTIDKK
RVIKKIGKLKKSDIVSIKSVLNEMLIE

Download         Length: 324 bp

>AT118534 NZ_CP035807:1407305-1407628 [Thiospirochaeta perfilievii]
ATGGTAATAAATCAATATGATATTTTACTTGTAAACCTAGATCATACAGTAGGTCATGAAATTCAAAAAACACGTCCATG
TGTTGTAATTTCACCGGATGAAATGAATCATTCTATAAAAACAGTCATAATTTCACCAATGACAACTAAATCTCATAATT
ACCCTACACGGATATCCATAACTTTTGAGAAAAAAGATGGTTGGGTTGTTTTAGATCAAATTAGAACGATTGATAAAAAA
AGAGTTATTAAAAAAATTGGAAAGTTAAAAAAGAGTGATATTGTAAGCATTAAAAGTGTTTTAAACGAGATGTTGATAGA
ATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References