Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/MazF(toxin)
Location 231161..231731 Replicon chromosome
Accession NZ_CP035807
Organism Thiospirochaeta perfilievii strain P

Toxin (Protein)


Gene name chpK Uniprot ID -
Locus tag EW093_RS01020 Protein ID WP_149566604.1
Coordinates 231161..231502 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID -
Locus tag EW093_RS01025 Protein ID WP_149566605.1
Coordinates 231489..231731 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW093_RS00985 226242..226547 - 306 WP_149566597.1 hypothetical protein -
EW093_RS00990 226558..226998 - 441 WP_149566598.1 JAB domain-containing protein -
EW093_RS00995 227154..227600 - 447 WP_149566599.1 hypothetical protein -
EW093_RS01000 227715..228128 - 414 WP_149566600.1 hypothetical protein -
EW093_RS01005 228558..229757 - 1200 WP_149566601.1 hypothetical protein -
EW093_RS01010 229824..230534 - 711 WP_149566602.1 MBL fold metallo-hydrolase -
EW093_RS01015 230735..231067 + 333 WP_149566603.1 single-stranded DNA-binding protein -
EW093_RS01020 231161..231502 - 342 WP_149566604.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EW093_RS01025 231489..231731 - 243 WP_149566605.1 ChpI protein Antitoxin
EW093_RS01030 232279..232776 - 498 WP_149566606.1 hypothetical protein -
EW093_RS01035 233844..234659 - 816 WP_149566607.1 hypothetical protein -
EW093_RS01040 234818..235342 - 525 WP_149566608.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12616.52 Da        Isoelectric Point: 5.0916

>T118532 WP_149566604.1 NZ_CP035807:c231502-231161 [Thiospirochaeta perfilievii]
MIRGEVWWADLGIPFGSEPGFKRPVVIIQDDSFNRSNIQTIIVSSVTTNLNLADAPGNIFLEPEESGLPKNGVINISQIS
TIDKRRLIEKVSTLPPRTMHEVDFGLKLIFNIQ

Download         Length: 342 bp

>T118532 NZ_CP035807:c231502-231161 [Thiospirochaeta perfilievii]
ATGATTCGTGGTGAAGTTTGGTGGGCTGACTTGGGAATTCCATTTGGAAGCGAACCAGGATTTAAAAGACCTGTTGTCAT
AATACAAGATGATTCATTTAATAGAAGTAATATTCAAACAATAATAGTATCTTCTGTAACTACAAATCTTAATCTTGCAG
ATGCACCTGGAAATATATTTTTAGAACCTGAAGAATCTGGATTACCTAAGAATGGAGTAATTAATATTTCCCAAATCTCA
ACAATAGACAAAAGAAGGCTAATAGAAAAAGTTAGTACTCTACCACCAAGAACAATGCATGAAGTTGATTTTGGGTTAAA
ACTTATTTTCAATATTCAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9216.36 Da        Isoelectric Point: 4.6510

>AT118532 WP_149566605.1 NZ_CP035807:c231731-231489 [Thiospirochaeta perfilievii]
MKTAISIPDNVYNDAEITAKELGLARSQLYVLAIKEFIEHHSKDRITEKLNCLFSKENNIEDTNELGLESLRKATEYDSW

Download         Length: 243 bp

>AT118532 NZ_CP035807:c231731-231489 [Thiospirochaeta perfilievii]
ATGAAAACTGCAATTTCAATACCTGATAACGTTTACAATGATGCTGAGATAACTGCAAAAGAGCTTGGATTAGCCAGAAG
CCAGTTATACGTATTAGCAATAAAAGAATTTATTGAGCATCATAGTAAAGATCGAATTACAGAAAAGCTAAATTGCTTAT
TCTCTAAGGAAAATAACATTGAAGATACAAATGAATTAGGGCTTGAATCATTAAGAAAGGCAACTGAATATGATTCGTGG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References