Detailed information of TA system TA118530

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 2171249..2171769
• Replicon: chromosome
• Accession: NZ_CP035806
• Organism: Leucobacter triazinivorans strain JW-1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: EVS81_RS09895
• Protein ID: WP_130110250.1
• Coordinates: 2171479..2171769 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: EVS81_RS09890
• Protein ID: WP_130110249.1
• Coordinates: 2171249..2171482 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EVS81_RS09875	2167530..2168831	+	1302	WP_130110246.1	MFS transporter	-
EVS81_RS09880	2168831..2170612	+	1782	WP_130110247.1	glycoside hydrolase family 3 protein	-
EVS81_RS09885	2170873..2171184	+	312	WP_130110248.1	thiamine-binding protein	-
EVS81_RS09890	2171249..2171482	+	234	WP_130110249.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
EVS81_RS09895	2171479..2171769	+	291	WP_130110250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EVS81_RS09900	2172171..2173040	+	870	WP_130110251.1	glucose-1-phosphate thymidylyltransferase RfbA	-
EVS81_RS09905	2173040..2174041	+	1002	WP_165384238.1	dTDP-glucose 4,6-dehydratase	-
EVS81_RS09910	2174044..2175456	+	1413	WP_130110252.1	dTDP-4-dehydrorhamnose reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (1-76)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11292.75 Da
• Isoelectric Point: 7.2769

>T118530 WP_130110250.1 NZ_CP035806:2171479-2171769 [Leucobacter triazinivorans]
MTGYRLTPAARRDLSSIWDFTRESWDVRQAETYVIEIRAAIERIADDPGRGRACDEIREGYRRYGIGSHLLFYIERGEGV
DVIRILHQRMDPTRHL

Nucleotide

• Length: 291 bp

>T118530 NZ_CP035806:2171479-2171769 [Leucobacter triazinivorans]
ATGACCGGCTACCGTCTCACTCCTGCCGCCCGACGCGACCTCTCCTCCATATGGGATTTCACCCGGGAGAGCTGGGACGT
GCGCCAGGCCGAGACCTATGTGATCGAGATCCGGGCCGCGATAGAGCGCATCGCCGACGACCCCGGACGGGGCCGTGCCT
GCGATGAGATCCGCGAGGGCTACCGCCGATACGGCATCGGCAGTCACCTGCTCTTCTACATCGAGCGAGGGGAAGGCGTG
GACGTGATCCGGATCCTGCACCAGCGCATGGACCCGACGCGGCACCTGTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8364.27 Da
• Isoelectric Point: 4.5680

>AT118530 WP_130110249.1 NZ_CP035806:2171249-2171482 [Leucobacter triazinivorans]
MAQNTSISLDSHFSDFLSREVSSGRYRSASEVIRAGLRLLEDQETRLAALRAALVAGEESGEAEPFDFDAFVAAKKA

Nucleotide

• Length: 234 bp

>AT118530 NZ_CP035806:2171249-2171482 [Leucobacter triazinivorans]
ATGGCTCAGAACACCTCGATCAGCTTGGATTCGCACTTCTCGGACTTCCTCTCACGCGAGGTCTCCTCCGGCCGCTACCG
GTCCGCCAGTGAGGTCATCCGCGCAGGGCTCCGGCTGCTGGAGGACCAGGAGACTCGGCTGGCGGCTCTGCGCGCCGCCC
TCGTCGCCGGCGAGGAGAGCGGAGAGGCTGAGCCCTTCGACTTCGACGCGTTCGTCGCGGCGAAGAAGGCATGA