Detailed information of TA system TA118526

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2745753..2746282
• Replicon: chromosome
• Accession: NZ_CP035791
• Organism: Staphylococcus aureus strain 592

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: ERW13_RS14220
• Protein ID: WP_000621175.1
• Coordinates: 2745920..2746282 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: ERW13_RS14215
• Protein ID: WP_000948331.1
• Coordinates: 2745753..2745923 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ERW13_RS14185	2740790..2741350	+	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-
ERW13_RS14190	2741558..2742037	+	480	WP_001287087.1	hypothetical protein	-
ERW13_RS14195	2742030..2743613	+	1584	WP_001294626.1	PH domain-containing protein	-
ERW13_RS14200	2743600..2744091	+	492	WP_001205912.1	PH domain-containing protein	-
ERW13_RS14205	2744095..2744454	+	360	WP_000581197.1	holo-ACP synthase	-
ERW13_RS14210	2744520..2745668	+	1149	WP_001281154.1	alanine racemase	-
ERW13_RS14215	2745753..2745923	+	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
ERW13_RS14220	2745920..2746282	+	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
ERW13_RS14230	2746632..2747633	+	1002	WP_000390827.1	PP2C family protein-serine/threonine phosphatase	-
ERW13_RS14235	2747752..2748078	+	327	WP_001052491.1	anti-sigma factor antagonist	-
ERW13_RS14240	2748080..2748559	+	480	WP_001190829.1	anti-sigma B factor RsbW	-
ERW13_RS14245	2748534..2749304	+	771	WP_001041111.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T118526 WP_000621175.1 NZ_CP035791:2745920-2746282 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T118526 NZ_CP035791:2745920-2746282 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT118526 WP_000948331.1 NZ_CP035791:2745753-2745923 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT118526 NZ_CP035791:2745753-2745923 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1