Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2350641..2351164 Replicon chromosome
Accession NZ_CP035791
Organism Staphylococcus aureus strain 592

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag ERW13_RS12055 Protein ID WP_000074049.1
Coordinates 2350898..2351164 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag ERW13_RS12050 Protein ID WP_000587616.1
Coordinates 2350641..2350898 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ERW13_RS12030 2347138..2347887 - 750 WP_000072461.1 CPBP family intramembrane metalloprotease -
ERW13_RS12035 2348082..2349659 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
ERW13_RS12040 2349827..2350282 - 456 WP_000732076.1 DUF1307 domain-containing protein -
ERW13_RS12050 2350641..2350898 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ERW13_RS12055 2350898..2351164 + 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
ERW13_RS12060 2351519..2352595 + 1077 WP_001076673.1 M42 family metallopeptidase -
ERW13_RS12065 2352843..2353505 + 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
ERW13_RS12070 2353498..2354274 + 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
ERW13_RS12075 2354670..2355857 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T118517 WP_000074049.1 NZ_CP035791:2350898-2351164 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T118517 NZ_CP035791:2350898-2351164 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT118517 WP_000587616.1 NZ_CP035791:2350641-2350898 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT118517 NZ_CP035791:2350641-2350898 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References