Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1206550..1207027 Replicon chromosome
Accession NZ_CP035791
Organism Staphylococcus aureus strain 592

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag ERW13_RS06410 Protein ID WP_000052076.1
Coordinates 1206839..1207027 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag ERW13_RS06405 Protein ID WP_001059690.1
Coordinates 1206550..1206810 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ERW13_RS06365 1201943..1202659 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
ERW13_RS06370 1202807..1203229 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
ERW13_RS06380 1203628..1204122 + 495 WP_000569883.1 GNAT family N-acetyltransferase -
ERW13_RS06385 1204277..1204894 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
ERW13_RS06390 1204967..1205548 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
ERW13_RS06395 1205773..1206009 + 237 WP_000349581.1 hypothetical protein -
ERW13_RS06400 1206006..1206209 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
ERW13_RS06405 1206550..1206810 + 261 WP_001059690.1 hypothetical protein Antitoxin
ERW13_RS06410 1206839..1207027 + 189 WP_000052076.1 hypothetical protein Toxin
ERW13_RS06415 1207215..1207784 + 570 WP_001106658.1 hypothetical protein -
ERW13_RS06420 1207872..1208141 + 270 WP_001004398.1 hypothetical protein -
ERW13_RS06425 1208218..1208436 + 219 WP_000005886.1 hypothetical protein -
ERW13_RS06430 1208928..1209128 - 201 WP_001059082.1 cold-shock protein -
ERW13_RS06435 1209485..1210171 - 687 WP_000141557.1 thermonuclease family protein -
ERW13_RS06440 1210512..1211033 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 1140862..1220639 79777


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

Antitoxin ParD

(1-77)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T118516 WP_000052076.1 NZ_CP035791:1206839-1207027 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T118516 NZ_CP035791:1206839-1207027 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT118516 WP_001059690.1 NZ_CP035791:1206550-1206810 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT118516 NZ_CP035791:1206550-1206810 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References