Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RHH
Location 3423451..3423893 Replicon chromosome
Accession NZ_CP035765
Organism Sphingomonas paucimobilis strain AIMST S2

Toxin (Protein)


Gene name relE Uniprot ID A0A0C9M624
Locus tag DRN02_RS16025 Protein ID WP_007406919.1
Coordinates 3423451..3423726 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0C9MYZ0
Locus tag DRN02_RS16030 Protein ID WP_007406923.1
Coordinates 3423714..3423893 (-) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DRN02_RS16005 3419024..3419476 + 453 WP_007406920.1 large conductance mechanosensitive channel protein MscL -
DRN02_RS16010 3419631..3420062 - 432 WP_007406932.1 Rrf2 family transcriptional regulator -
DRN02_RS16020 3420853..3423423 - 2571 WP_007406927.1 DNA mismatch repair protein MutS -
DRN02_RS16025 3423451..3423726 - 276 WP_007406919.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DRN02_RS16030 3423714..3423893 - 180 WP_007406923.1 antitoxin Antitoxin
DRN02_RS16035 3424026..3426284 + 2259 WP_007406925.1 NADP-dependent malic enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10372.73 Da        Isoelectric Point: 5.5940

>T118403 WP_007406919.1 NZ_CP035765:c3423726-3423451 [Sphingomonas paucimobilis]
MAQISWSVQASLQLAAIVDYIEQFDPDAARRLGDRLIDVAESLRQFPDRGRPISHGRREMVTVRPYVLRYEHDGETVLIL
GIRHAAQLSDD

Download         Length: 276 bp

>T118403 NZ_CP035765:c3423726-3423451 [Sphingomonas paucimobilis]
ATGGCTCAAATAAGCTGGTCGGTTCAGGCCTCGCTCCAACTCGCCGCGATCGTCGATTATATAGAGCAGTTCGATCCCGA
CGCCGCCCGGCGCTTGGGTGACAGGCTGATCGACGTCGCCGAATCCTTGCGGCAATTCCCGGATCGCGGCAGGCCCATTT
CCCATGGCCGCCGCGAGATGGTGACGGTTCGCCCCTATGTCCTGCGCTATGAGCATGACGGCGAGACCGTCCTGATCCTC
GGCATTCGCCACGCCGCCCAACTTTCCGACGATTGA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6906.77 Da        Isoelectric Point: 5.1023

>AT118403 WP_007406923.1 NZ_CP035765:c3423893-3423714 [Sphingomonas paucimobilis]
MEHEPGIFEQRDEAAELAADERARADFKAGRFVSHEKMAEWLKTWGTPDRKPLPPEWLK

Download         Length: 180 bp

>AT118403 NZ_CP035765:c3423893-3423714 [Sphingomonas paucimobilis]
ATGGAGCATGAGCCCGGCATTTTCGAGCAGCGTGACGAGGCGGCGGAACTGGCCGCCGACGAACGCGCACGGGCCGATTT
CAAGGCGGGCCGTTTCGTAAGCCATGAGAAGATGGCCGAATGGCTGAAGACCTGGGGCACCCCCGATCGCAAGCCCCTGC
CCCCCGAATGGCTCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C9M624

Antitoxin

Source ID Structure
AlphaFold DB A0A0C9MYZ0

References