Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 27477..27942 Replicon plasmid pE110019_33
Accession NZ_CP035754
Organism Escherichia coli E110019

Toxin (Protein)


Gene name TsxA Uniprot ID A0A5Y6UAV0
Locus tag ECE110019_RS26785 Protein ID WP_001230708.1
Coordinates 27477..27728 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID M7CCF8
Locus tag ECE110019_RS26790 Protein ID WP_000801440.1
Coordinates 27715..27942 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECE110019_RS26765 24997..25332 + 336 WP_001147119.1 type II toxin-antitoxin system RelE/ParE family toxin -
ECE110019_RS26770 25329..25679 + 351 WP_000127483.1 hypothetical protein -
ECE110019_RS26775 26318..26833 + 516 WP_001025396.1 J domain-containing protein -
ECE110019_RS26780 26938..27480 + 543 WP_001083908.1 hypothetical protein -
ECE110019_RS26785 27477..27728 + 252 WP_001230708.1 hypothetical protein Toxin
ECE110019_RS26790 27715..27942 + 228 WP_000801440.1 hypothetical protein Antitoxin
ECE110019_RS26795 28335..28634 + 300 WP_000650313.1 hypothetical protein -
ECE110019_RS26800 28726..29091 + 366 WP_000854262.1 hypothetical protein -
ECE110019_RS26805 29333..29539 + 207 WP_000882678.1 type II toxin-antitoxin system HicB family antitoxin -
ECE110019_RS26810 29902..30405 + 504 WP_000781818.1 hypothetical protein -
ECE110019_RS26815 30409..31638 + 1230 WP_000539545.1 relaxase/mobilization nuclease domain-containing protein -
ECE110019_RS26820 31715..32008 + 294 WP_000134733.1 LuxR family transcriptional regulator -
ECE110019_RS26825 32005..32220 + 216 WP_000760375.1 EexN family lipoprotein -
ECE110019_RS26830 32397..32573 + 177 WP_000660496.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..33827 33827


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9750.19 Da        Isoelectric Point: 9.8104

>T118402 WP_001230708.1 NZ_CP035754:27477-27728 [Escherichia coli E110019]
MRKNKGDVTYFLEKEGDNYRLTKRIKARTNVKIGNKTTKITLYDAVLNENELQHIDFTCAGLRKDDETPVKNLIKEFMLN
ETR

Download         Length: 252 bp

>T118402 NZ_CP035754:27477-27728 [Escherichia coli E110019]
ATGAGAAAAAATAAAGGTGATGTGACTTATTTTCTTGAAAAAGAAGGTGACAATTACAGGCTTACAAAAAGGATAAAAGC
CAGAACAAATGTTAAAATCGGGAACAAAACTACGAAAATCACATTGTATGATGCCGTACTGAATGAGAATGAATTACAAC
ATATTGATTTTACGTGTGCCGGATTAAGGAAAGACGATGAGACGCCAGTTAAGAATTTAATTAAGGAGTTTATGTTAAAT
GAAACCCGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8659.98 Da        Isoelectric Point: 8.5105

>AT118402 WP_000801440.1 NZ_CP035754:27715-27942 [Escherichia coli E110019]
MKPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQKKEEVNTQNSQSLSLVEFEFLLLLAGEHPEYVLCKRESK

Download         Length: 228 bp

>AT118402 NZ_CP035754:27715-27942 [Escherichia coli E110019]
ATGAAACCCGATAATACACCTGAAAATGTAAAAAAATTACGTTTAAAAGCAGGATTAACACAAAAGGAATGCAGTCATAT
TTATGGTGTTGGGCTAAGAACCTGGCAGAAAAAAGAGGAAGTTAATACTCAAAACAGTCAAAGTCTGTCACTGGTTGAGT
TTGAGTTTCTTTTGTTACTTGCAGGAGAACATCCTGAATACGTGCTCTGCAAAAGGGAGTCAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y6UAV0

Antitoxin

Source ID Structure
AlphaFold DB A0A5Y6U8W9

References