Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2735703..2736538 | Replicon | chromosome |
| Accession | NZ_CP035751 | ||
| Organism | Escherichia coli E110019 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A136X5A2 |
| Locus tag | ECE110019_RS13610 | Protein ID | WP_000854757.1 |
| Coordinates | 2736161..2736538 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | ECE110019_RS13605 | Protein ID | WP_024184487.1 |
| Coordinates | 2735703..2736071 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ECE110019_RS13580 | 2733066..2733224 | + | 159 | WP_048818827.1 | DUF905 family protein | - |
| ECE110019_RS13585 | 2733379..2734197 | + | 819 | WP_001234716.1 | DUF945 domain-containing protein | - |
| ECE110019_RS13590 | 2734279..2734758 | + | 480 | WP_000844095.1 | antirestriction protein | - |
| ECE110019_RS13595 | 2734774..2735250 | + | 477 | WP_001186770.1 | RadC family protein | - |
| ECE110019_RS13600 | 2735319..2735540 | + | 222 | WP_000584198.1 | DUF987 domain-containing protein | - |
| ECE110019_RS13605 | 2735703..2736071 | + | 369 | WP_024184487.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| ECE110019_RS13610 | 2736161..2736538 | + | 378 | WP_000854757.1 | TA system toxin CbtA family protein | Toxin |
| ECE110019_RS13615 | 2736535..2736738 | + | 204 | WP_000761705.1 | hypothetical protein | - |
| ECE110019_RS13620 | 2736751..2736864 | + | 114 | WP_032140621.1 | DUF957 domain-containing protein | - |
| ECE110019_RS13625 | 2737020..2737490 | - | 471 | Protein_2671 | IS21-like element ISEc12 family helper ATPase IstB | - |
| ECE110019_RS13630 | 2737578..2738003 | + | 426 | WP_000422741.1 | IS66 family insertion sequence hypothetical protein | - |
| ECE110019_RS13635 | 2738000..2738350 | + | 351 | WP_000624722.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| ECE110019_RS13640 | 2738381..2739994 | + | 1614 | WP_016236744.1 | IS66-like element ISEc23 family transposase | - |
| ECE110019_RS13645 | 2740016..2740108 | - | 93 | Protein_2675 | ATP-binding protein | - |
| ECE110019_RS13655 | 2740303..2740485 | + | 183 | WP_024167529.1 | ethanolamine utilization protein | - |
| ECE110019_RS13660 | 2740586..2740915 | - | 330 | WP_000450409.1 | DUF496 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14153.18 Da Isoelectric Point: 7.3249
>T118388 WP_000854757.1 NZ_CP035751:2736161-2736538 [Escherichia coli E110019]
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
Download Length: 378 bp
>T118388 NZ_CP035751:2736161-2736538 [Escherichia coli E110019]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13582.36 Da Isoelectric Point: 6.6255
>AT118388 WP_024184487.1 NZ_CP035751:2735703-2736071 [Escherichia coli E110019]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTSETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTSETKK
Download Length: 369 bp
>AT118388 NZ_CP035751:2735703-2736071 [Escherichia coli E110019]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|