Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2171026..2171552 | Replicon | chromosome |
| Accession | NZ_CP035751 | ||
| Organism | Escherichia coli E110019 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | ECE110019_RS10695 | Protein ID | WP_000323025.1 |
| Coordinates | 2171265..2171552 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | ECE110019_RS10690 | Protein ID | WP_000534858.1 |
| Coordinates | 2171026..2171265 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ECE110019_RS10655 | 2166240..2166413 | - | 174 | Protein_2091 | DUF2514 family protein | - |
| ECE110019_RS10660 | 2166469..2167682 | + | 1214 | WP_165899066.1 | IS3 family transposase | - |
| ECE110019_RS10665 | 2167726..2167953 | - | 228 | Protein_2093 | FlxA-like family protein | - |
| ECE110019_RS10670 | 2168007..2169620 | - | 1614 | WP_016236744.1 | IS66-like element ISEc23 family transposase | - |
| ECE110019_RS10675 | 2169651..2170001 | - | 351 | WP_000624722.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| ECE110019_RS10680 | 2169998..2170423 | - | 426 | WP_000422741.1 | IS66 family insertion sequence hypothetical protein | - |
| ECE110019_RS10685 | 2170696..2171001 | - | 306 | WP_001326990.1 | hypothetical protein | - |
| ECE110019_RS10690 | 2171026..2171265 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| ECE110019_RS10695 | 2171265..2171552 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| ECE110019_RS10700 | 2171624..2171779 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| ECE110019_RS10705 | 2171996..2172247 | + | 252 | WP_000980994.1 | hypothetical protein | - |
| ECE110019_RS10710 | 2172314..2172592 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| ECE110019_RS10715 | 2172594..2173643 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| ECE110019_RS10720 | 2173657..2174409 | + | 753 | WP_001047137.1 | antitermination protein | - |
| ECE110019_RS10725 | 2174687..2174776 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| ECE110019_RS10730 | 2174831..2175043 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| ECE110019_RS10735 | 2175344..2175559 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2134754..2184305 | 49551 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T118379 WP_000323025.1 NZ_CP035751:2171265-2171552 [Escherichia coli E110019]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T118379 NZ_CP035751:2171265-2171552 [Escherichia coli E110019]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT118379 WP_000534858.1 NZ_CP035751:2171026-2171265 [Escherichia coli E110019]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT118379 NZ_CP035751:2171026-2171265 [Escherichia coli E110019]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|