Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1506322..1507117 Replicon chromosome
Accession NZ_CP035751
Organism Escherichia coli E110019

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag ECE110019_RS07305 Protein ID WP_000854914.1
Coordinates 1506743..1507117 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9LM11
Locus tag ECE110019_RS07300 Protein ID WP_001280953.1
Coordinates 1506322..1506696 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECE110019_RS07270 1501677..1502582 + 906 WP_000203541.1 chemotaxis protein -
ECE110019_RS07275 1502579..1503649 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
ECE110019_RS07280 1503989..1504807 + 819 WP_001234682.1 DUF945 domain-containing protein -
ECE110019_RS07285 1504898..1505383 + 486 WP_000214398.1 antirestriction protein -
ECE110019_RS07290 1505399..1505875 + 477 WP_001299629.1 RadC family protein -
ECE110019_RS07295 1505938..1506159 + 222 WP_000692323.1 DUF987 domain-containing protein -
ECE110019_RS07300 1506322..1506696 + 375 WP_001280953.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ECE110019_RS07305 1506743..1507117 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
ECE110019_RS07310 1507114..1507605 + 492 WP_000976857.1 hypothetical protein -
ECE110019_RS07315 1507617..1507814 + 198 WP_000839282.1 DUF957 domain-containing protein -
ECE110019_RS07320 1507899..1508741 + 843 WP_001280481.1 DUF4942 domain-containing protein -
ECE110019_RS07330 1509212..1510150 + 939 WP_000351308.1 glyoxylate/hydroxypyruvate reductase GhrA -
ECE110019_RS07335 1510205..1510942 + 738 WP_000283664.1 zinc-binding phosphatase -
ECE110019_RS07340 1510966..1511520 + 555 WP_001001902.1 molecular chaperone YcdY -
ECE110019_RS07345 1511622..1512113 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 1505399..1537300 31901


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T118376 WP_000854914.1 NZ_CP035751:1506743-1507117 [Escherichia coli E110019]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T118376 NZ_CP035751:1506743-1507117 [Escherichia coli E110019]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13734.56 Da        Isoelectric Point: 6.6249

>AT118376 WP_001280953.1 NZ_CP035751:1506322-1506696 [Escherichia coli E110019]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPALATTS

Download         Length: 375 bp

>AT118376 NZ_CP035751:1506322-1506696 [Escherichia coli E110019]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACTCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LM11

References