Detailed information of TA system TA118369

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 3935945..3936450
• Replicon: chromosome
• Accession: NZ_CP035739
• Organism: Pseudomonas aeruginosa strain 1334/14

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: EWS90_RS19220
• Protein ID: WP_034037564.1
• Coordinates: 3936169..3936450 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: EWS90_RS19215
• Protein ID: WP_003083775.1
• Coordinates: 3935945..3936172 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EWS90_RS19190	3930963..3932456	+	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-
EWS90_RS19195	3932625..3934052	+	1428	WP_003083784.1	GABA permease	-
EWS90_RS19200	3934134..3934475	-	342	WP_003101229.1	alkylphosphonate utilization protein	-
EWS90_RS19205	3934548..3935048	-	501	WP_003101228.1	LEA type 2 family protein	-
EWS90_RS19210	3935149..3935769	+	621	WP_130021887.1	hypothetical protein	-
EWS90_RS19215	3935945..3936172	+	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
EWS90_RS19220	3936169..3936450	+	282	WP_034037564.1	type II toxin-antitoxin system toxin ParE	Toxin
EWS90_RS19225	3936750..3937658	+	909	WP_016561475.1	LysR family transcriptional regulator	-
EWS90_RS19230	3937690..3938076	-	387	WP_014602345.1	aegerolysin family protein	-
EWS90_RS19235	3938280..3939014	-	735	WP_003117208.1	GntR family transcriptional regulator	-
EWS90_RS19240	3939115..3939801	-	687	WP_003083762.1	FadR family transcriptional regulator	-
EWS90_RS19245	3939850..3941199	-	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10458.20 Da
• Isoelectric Point: 10.0435

>T118369 WP_034037564.1 NZ_CP035739:3936169-3936450 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLPLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T118369 NZ_CP035739:3936169-3936450 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGCCCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT118369 WP_003083775.1 NZ_CP035739:3935945-3936172 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT118369 NZ_CP035739:3935945-3936172 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1C7BDS9