Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-ParD |
| Location | 2945348..2946333 | Replicon | chromosome |
| Accession | NZ_CP035734 | ||
| Organism | Mycolicibacterium monacense DSM 44395 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | A0A1X0H0L6 |
| Locus tag | EWR22_RS14125 | Protein ID | WP_011560054.1 |
| Coordinates | 2945755..2946333 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | A0A1X0H0D6 |
| Locus tag | EWR22_RS14120 | Protein ID | WP_011560053.1 |
| Coordinates | 2945348..2945740 (+) | Length | 131 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EWR22_RS14090 (EWR22_14120) | 2940526..2941278 | - | 753 | WP_011855719.1 | SDR family oxidoreductase | - |
| EWR22_RS14095 (EWR22_14125) | 2941427..2942059 | + | 633 | WP_041310156.1 | FKBP-type peptidyl-prolyl cis-trans isomerase | - |
| EWR22_RS14100 (EWR22_14130) | 2942063..2942470 | - | 408 | WP_011560049.1 | pyridoxamine 5'-phosphate oxidase family protein | - |
| EWR22_RS14105 (EWR22_14135) | 2942583..2943596 | + | 1014 | WP_011768229.1 | acetamidase/formamidase family protein | - |
| EWR22_RS14110 (EWR22_14140) | 2943607..2944368 | + | 762 | WP_011560051.1 | SDR family NAD(P)-dependent oxidoreductase | - |
| EWR22_RS14115 (EWR22_14145) | 2944373..2945239 | - | 867 | WP_179967744.1 | EamA family transporter | - |
| EWR22_RS14120 (EWR22_14150) | 2945348..2945740 | + | 393 | WP_011560053.1 | hypothetical protein | Antitoxin |
| EWR22_RS14125 (EWR22_14155) | 2945755..2946333 | + | 579 | WP_011560054.1 | zeta toxin family protein | Toxin |
| EWR22_RS14130 (EWR22_14160) | 2946560..2947981 | + | 1422 | WP_011560055.1 | rifampin monooxygenase | - |
| EWR22_RS14135 (EWR22_14165) | 2948010..2949080 | + | 1071 | WP_011855720.1 | aldo/keto reductase | - |
| EWR22_RS14140 (EWR22_14170) | 2949090..2949452 | + | 363 | WP_011560057.1 | RNA-binding S4 domain-containing protein | - |
| EWR22_RS14145 (EWR22_14175) | 2949502..2950275 | + | 774 | WP_011560058.1 | enoyl-CoA hydratase/isomerase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21319.14 Da Isoelectric Point: 8.1325
>T118344 WP_011560054.1 NZ_CP035734:2945755-2946333 [Mycolicibacterium monacense DSM 44395]
MRRLDLVIGPNGAGKSTFVAFTLAPLLPGSPFVNADEIARQRWPDDAEQHSYEAARIAAATRSALIRSGRSFIAETVFSH
PSKLDLIAEAHGRDYTVVVHVLLVPEDLSVERVRHRVLAGGHRVSEDKIRERYRRLWDLAAQAIESCDSATVYDNSRRRG
PRIVAQFTGGEPIGAPAWPEWTPAPLVQHWPA
MRRLDLVIGPNGAGKSTFVAFTLAPLLPGSPFVNADEIARQRWPDDAEQHSYEAARIAAATRSALIRSGRSFIAETVFSH
PSKLDLIAEAHGRDYTVVVHVLLVPEDLSVERVRHRVLAGGHRVSEDKIRERYRRLWDLAAQAIESCDSATVYDNSRRRG
PRIVAQFTGGEPIGAPAWPEWTPAPLVQHWPA
Download Length: 579 bp
>T118344 NZ_CP035734:2945755-2946333 [Mycolicibacterium monacense DSM 44395]
ATGCGCCGACTCGACCTCGTCATCGGGCCGAACGGGGCCGGTAAGTCCACCTTCGTCGCGTTCACCCTGGCGCCGCTGCT
GCCGGGCAGCCCGTTCGTCAACGCCGACGAGATCGCCAGGCAGCGCTGGCCCGACGATGCGGAGCAGCACTCCTACGAGG
CGGCCCGGATCGCGGCCGCCACGCGCAGCGCCCTGATCCGTTCGGGTCGCTCCTTCATCGCCGAGACGGTGTTCTCCCAT
CCCTCGAAGCTGGACCTCATCGCCGAAGCGCACGGCCGCGACTACACCGTCGTCGTGCACGTCTTGTTGGTCCCCGAGGA
TCTGTCGGTGGAACGCGTGCGGCATCGCGTACTCGCCGGCGGGCACCGCGTCTCGGAGGACAAGATCCGCGAACGATACC
GCCGGCTATGGGATCTCGCGGCTCAGGCGATCGAATCATGTGACAGTGCAACCGTTTACGACAACAGCCGCCGACGCGGA
CCGAGGATCGTGGCCCAGTTCACCGGCGGTGAGCCGATCGGCGCGCCGGCGTGGCCGGAGTGGACACCGGCGCCACTGGT
GCAGCACTGGCCTGCCTGA
ATGCGCCGACTCGACCTCGTCATCGGGCCGAACGGGGCCGGTAAGTCCACCTTCGTCGCGTTCACCCTGGCGCCGCTGCT
GCCGGGCAGCCCGTTCGTCAACGCCGACGAGATCGCCAGGCAGCGCTGGCCCGACGATGCGGAGCAGCACTCCTACGAGG
CGGCCCGGATCGCGGCCGCCACGCGCAGCGCCCTGATCCGTTCGGGTCGCTCCTTCATCGCCGAGACGGTGTTCTCCCAT
CCCTCGAAGCTGGACCTCATCGCCGAAGCGCACGGCCGCGACTACACCGTCGTCGTGCACGTCTTGTTGGTCCCCGAGGA
TCTGTCGGTGGAACGCGTGCGGCATCGCGTACTCGCCGGCGGGCACCGCGTCTCGGAGGACAAGATCCGCGAACGATACC
GCCGGCTATGGGATCTCGCGGCTCAGGCGATCGAATCATGTGACAGTGCAACCGTTTACGACAACAGCCGCCGACGCGGA
CCGAGGATCGTGGCCCAGTTCACCGGCGGTGAGCCGATCGGCGCGCCGGCGTGGCCGGAGTGGACACCGGCGCCACTGGT
GCAGCACTGGCCTGCCTGA
Antitoxin
Download Length: 131 a.a. Molecular weight: 13705.22 Da Isoelectric Point: 4.9341
>AT118344 WP_011560053.1 NZ_CP035734:2945348-2945740 [Mycolicibacterium monacense DSM 44395]
MADVADRVTRVAADLIDSAAVEGARQSRSAKQQLDHWARVGRAVSSHHTAARRRVEAALAGVAGLDTLNREEGVVFNAEI
SAAIEERLAGADYGELLAARGITTVALDDAGRIVQYRPDGTSVVLDDTPA
MADVADRVTRVAADLIDSAAVEGARQSRSAKQQLDHWARVGRAVSSHHTAARRRVEAALAGVAGLDTLNREEGVVFNAEI
SAAIEERLAGADYGELLAARGITTVALDDAGRIVQYRPDGTSVVLDDTPA
Download Length: 393 bp
>AT118344 NZ_CP035734:2945348-2945740 [Mycolicibacterium monacense DSM 44395]
ATGGCTGACGTCGCCGACCGGGTGACTCGCGTCGCCGCCGATCTGATCGACAGTGCGGCGGTCGAGGGCGCACGCCAGAG
CCGCTCTGCCAAACAGCAACTCGACCACTGGGCGCGGGTCGGCCGGGCGGTGTCGAGTCACCACACCGCCGCCCGCAGGC
GCGTCGAAGCCGCGCTGGCCGGAGTAGCCGGCCTCGACACCCTCAACCGCGAGGAGGGCGTGGTCTTCAACGCCGAGATC
TCCGCGGCGATCGAGGAGCGGCTCGCCGGCGCCGACTACGGGGAACTGCTGGCGGCCCGCGGCATCACCACCGTCGCCCT
CGACGACGCCGGCCGGATCGTGCAGTACCGGCCCGACGGCACGTCGGTCGTCCTCGACGACACCCCGGCCTGA
ATGGCTGACGTCGCCGACCGGGTGACTCGCGTCGCCGCCGATCTGATCGACAGTGCGGCGGTCGAGGGCGCACGCCAGAG
CCGCTCTGCCAAACAGCAACTCGACCACTGGGCGCGGGTCGGCCGGGCGGTGTCGAGTCACCACACCGCCGCCCGCAGGC
GCGTCGAAGCCGCGCTGGCCGGAGTAGCCGGCCTCGACACCCTCAACCGCGAGGAGGGCGTGGTCTTCAACGCCGAGATC
TCCGCGGCGATCGAGGAGCGGCTCGCCGGCGCCGACTACGGGGAACTGCTGGCGGCCCGCGGCATCACCACCGTCGCCCT
CGACGACGCCGGCCGGATCGTGCAGTACCGGCCCGACGGCACGTCGGTCGTCCTCGACGACACCCCGGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1X0H0L6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1X0H0D6 |