Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2830653..2831281 Replicon chromosome
Accession NZ_CP035734
Organism Mycolicibacterium monacense DSM 44395

Toxin (Protein)


Gene name vapC Uniprot ID A0A1X0GQZ4
Locus tag EWR22_RS13560 Protein ID WP_064876250.1
Coordinates 2830653..2831063 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1X1SYP9
Locus tag EWR22_RS13565 Protein ID WP_064876252.1
Coordinates 2831054..2831281 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EWR22_RS13530 (EWR22_13560) 2826000..2827613 - 1614 WP_099050156.1 apolipoprotein N-acyltransferase -
EWR22_RS13535 (EWR22_13565) 2827790..2828431 - 642 WP_064872264.1 TlpA disulfide reductase family protein -
EWR22_RS13540 (EWR22_13570) 2828819..2829217 + 399 WP_179959971.1 metalloregulator ArsR/SmtB family transcription factor -
EWR22_RS13545 (EWR22_13575) 2829371..2829616 + 246 WP_249709735.1 signal peptidase II -
EWR22_RS13550 (EWR22_13580) 2829613..2830215 + 603 WP_064875957.1 cadmium resistance transporter -
EWR22_RS13555 (EWR22_13585) 2830283..2830411 + 129 Protein_2707 TlpA family protein disulfide reductase -
EWR22_RS13560 (EWR22_13590) 2830653..2831063 - 411 WP_064876250.1 PIN domain nuclease Toxin
EWR22_RS13565 (EWR22_13595) 2831054..2831281 - 228 WP_064876252.1 hypothetical protein Antitoxin
EWR22_RS13570 (EWR22_13600) 2831784..2832392 - 609 WP_013471561.1 cadmium resistance transporter -
EWR22_RS13575 (EWR22_13605) 2832564..2832953 - 390 WP_005148625.1 heavy metal-responsive transcriptional regulator -
EWR22_RS13580 (EWR22_13610) 2833010..2834413 + 1404 WP_005148655.1 mercury(II) reductase -
EWR22_RS13585 (EWR22_13615) 2834440..2835081 + 642 WP_005148656.1 organomercurial lyase MerB -
EWR22_RS13590 (EWR22_13620) 2835141..2835404 + 264 WP_235660419.1 hypothetical protein -
EWR22_RS13595 (EWR22_13625) 2835451..2835951 + 501 WP_238382207.1 redoxin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(12-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14846.02 Da        Isoelectric Point: 4.8950

>T118343 WP_064876250.1 NZ_CP035734:c2831063-2830653 [Mycolicibacterium monacense DSM 44395]
VAVTNWIIDKSAYTRLSASRDATAWIERIERGLVRISTVTRLEIGYSFRTGQQAREETASPPLSLMPVEYLTPAAEDRAV
AVQMLLADRGQHRAPAIPDLLVAATAELGGLTVLALDKDFDLIAQVTGQPVESLRM

Download         Length: 411 bp

>T118343 NZ_CP035734:c2831063-2830653 [Mycolicibacterium monacense DSM 44395]
GTGGCGGTGACTAATTGGATCATCGACAAATCCGCCTACACACGGCTATCGGCGTCGCGCGACGCCACGGCCTGGATCGA
ACGCATCGAACGCGGCCTCGTCCGCATCAGCACCGTCACCCGACTAGAAATCGGATACTCGTTCCGCACCGGCCAACAGG
CGCGCGAGGAGACAGCATCCCCTCCCCTGAGCCTGATGCCGGTCGAGTACTTGACACCGGCCGCTGAGGACCGCGCCGTC
GCGGTGCAAATGCTGCTGGCCGATCGCGGCCAGCACCGCGCCCCCGCCATTCCTGATCTTCTCGTCGCCGCGACCGCAGA
ACTCGGTGGGCTGACCGTGCTGGCGCTGGACAAGGACTTCGATCTCATCGCCCAGGTCACCGGTCAGCCCGTTGAGAGCC
TGCGGATGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8129.04 Da        Isoelectric Point: 4.7420

>AT118343 WP_064876252.1 NZ_CP035734:c2831281-2831054 [Mycolicibacterium monacense DSM 44395]
VSDVLIRGLSEGAVARIDADAAARGLSRQEYLRQRFEREGTVGATQRSLTLADLRRAEAAAADLDDPGVMDTAWR

Download         Length: 228 bp

>AT118343 NZ_CP035734:c2831281-2831054 [Mycolicibacterium monacense DSM 44395]
GTGAGCGACGTGCTGATCCGAGGATTGTCCGAGGGGGCGGTGGCGCGCATCGACGCCGACGCGGCCGCGCGCGGCCTGTC
CCGCCAAGAGTATCTGCGTCAGCGGTTCGAGCGCGAAGGGACAGTGGGCGCGACCCAGCGCTCGCTGACGCTGGCCGACC
TGCGCCGCGCTGAGGCCGCCGCCGCCGACCTCGACGATCCCGGCGTGATGGACACAGCGTGGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X0GQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1SYP9

References