Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 947706..948265 Replicon chromosome
Accession NZ_CP035732
Organism Vibrio vulnificus strain 2142-77

Toxin (Protein)


Gene name relE Uniprot ID Q7MFK6
Locus tag EPB55_RS20030 Protein ID WP_011151716.1
Coordinates 947706..947984 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3Q0L0M2
Locus tag EPB55_RS20035 Protein ID WP_011082348.1
Coordinates 947981..948265 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EPB55_RS20000 942755..943483 + 729 WP_072603589.1 MipA/OmpV family protein -
EPB55_RS20005 943701..944216 + 516 WP_103277280.1 lipocalin family protein -
EPB55_RS20010 945092..945679 + 588 WP_038939962.1 DUF1471 domain-containing protein -
EPB55_RS20015 946501..947001 + 501 WP_038939959.1 hypothetical protein -
EPB55_RS20020 947011..947265 + 255 Protein_797 hypothetical protein -
EPB55_RS20025 947546..947677 + 132 WP_130194419.1 DUF3265 domain-containing protein -
EPB55_RS20030 947706..947984 - 279 WP_011151716.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
EPB55_RS20035 947981..948265 - 285 WP_011082348.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EPB55_RS20040 948499..949308 + 810 WP_108678046.1 SUMF1/EgtB/PvdO family nonheme iron enzyme -
EPB55_RS20045 949548..949811 + 264 WP_015727534.1 hypothetical protein -
EPB55_RS20050 949889..950389 + 501 WP_015727533.1 hypothetical protein -
EPB55_RS20055 950469..951500 - 1032 WP_011082342.1 L-threonine 3-dehydrogenase -
EPB55_RS20060 951636..952829 - 1194 WP_011082341.1 glycine C-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(1-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-45)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10872.53 Da        Isoelectric Point: 4.3423

>T118341 WP_011151716.1 NZ_CP035732:c947984-947706 [Vibrio vulnificus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIHGRLLIIPEISMVISYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T118341 NZ_CP035732:c947984-947706 [Vibrio vulnificus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAATCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCACGGTCGATTACTCATTATTCCTGAGATTTCGATGGTTATCTCTTACTGGGTCGAGGGCGATATCATCCGAGTTATG
CGTGTCCTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11083.43 Da        Isoelectric Point: 9.2167

>AT118341 WP_011082348.1 NZ_CP035732:c948265-947981 [Vibrio vulnificus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFIEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT118341 NZ_CP035732:c948265-947981 [Vibrio vulnificus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTTAGTGACGCATGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTGTCTCACGATGCATGGCTAA
CTGAACAAGTAAATCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCATTGAGCACCAAACTGCTAAATCTCGA
ATGGAAGAGCGAAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7MFK6

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q0L0M2

References