Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 445446..445974 Replicon chromosome
Accession NZ_CP035731
Organism Vibrio vulnificus strain 2142-77

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag EPB55_RS02930 Protein ID WP_005377002.1
Coordinates 445684..445974 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7X8YMD8
Locus tag EPB55_RS02925 Protein ID WP_053805056.1
Coordinates 445446..445694 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EPB55_RS02875 440701..441162 - 462 WP_154142328.1 hypothetical protein -
EPB55_RS02880 441387..441644 - 258 WP_029858010.1 PnuC protein -
EPB55_RS02885 441793..442167 - 375 WP_130341808.1 hypothetical protein -
EPB55_RS02890 442184..442348 - 165 WP_154142330.1 DUF3265 domain-containing protein -
EPB55_RS02895 442332..442856 - 525 WP_195721971.1 GNAT family N-acetyltransferase -
EPB55_RS02900 442816..442983 - 168 WP_154142573.1 DUF3265 domain-containing protein -
EPB55_RS02905 443649..443836 - 188 Protein_576 DUF3265 domain-containing protein -
EPB55_RS02910 444171..444312 - 142 Protein_577 DUF3265 domain-containing protein -
EPB55_RS02915 444642..444770 - 129 Protein_578 DUF3265 domain-containing protein -
EPB55_RS02920 444775..445239 - 465 WP_111416397.1 ASCH domain-containing protein -
EPB55_RS23570 445303..445371 - 69 WP_074531725.1 DUF3265 domain-containing protein -
EPB55_RS02925 445446..445694 + 249 WP_053805056.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EPB55_RS02930 445684..445974 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EPB55_RS02935 446106..446636 - 531 WP_069498697.1 hypothetical protein -
EPB55_RS02940 446771..447268 - 498 WP_005433712.1 DNA topology modulation protein -
EPB55_RS02945 447424..447954 - 531 WP_154142332.1 DUF2628 domain-containing protein -
EPB55_RS02950 448093..448704 - 612 WP_025611401.1 hypothetical protein -
EPB55_RS02955 448724..448846 - 123 WP_154142578.1 DUF3265 domain-containing protein -
EPB55_RS02960 448856..449362 - 507 WP_039562375.1 GNAT family N-acetyltransferase -
EPB55_RS02965 449346..449543 - 198 WP_195721972.1 DUF3265 domain-containing protein -
EPB55_RS02970 449866..449958 - 93 WP_082309527.1 DUF3265 domain-containing protein -
EPB55_RS02975 449981..450418 - 438 WP_039562379.1 hypothetical protein -
EPB55_RS02980 450405..450578 - 174 WP_154142334.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 153034..526547 373513
- inside Integron - - 321930..452106 130176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T118340 WP_005377002.1 NZ_CP035731:445684-445974 [Vibrio vulnificus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T118340 NZ_CP035731:445684-445974 [Vibrio vulnificus]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCACTCAAAGAGTGGAAAAAACTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCAGCTTCAAAACTTTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTAATCATTGTAACCGTCTTAGCAGTCGGAAAA
CGAGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9049.34 Da        Isoelectric Point: 3.9610

>AT118340 WP_053805056.1 NZ_CP035731:445446-445694 [Vibrio vulnificus]
MTARILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT118340 NZ_CP035731:445446-445694 [Vibrio vulnificus]
ATGACTGCTAGAATTTTAGCCGATGTTGCTGCAAGCATTACCGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTATGGCGAACCTGTTGCTGTATTAAACCGAAATGAGCCAGCATTTTATTGCGTACCTGCTGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTAGCTATCGCTAAAGAGCGTGAGTCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A7X8YMD8

References