Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 306259..307025 Replicon chromosome
Accession NZ_CP035731
Organism Vibrio vulnificus strain 2142-77

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag EPB55_RS01525 Protein ID WP_130195057.1
Coordinates 306528..307025 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag EPB55_RS01520 Protein ID WP_130195056.1
Coordinates 306259..306531 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EPB55_RS01460 302021..302098 - 78 WP_074534512.1 DUF3265 domain-containing protein -
EPB55_RS01465 302132..302548 - 417 WP_021486673.1 VOC family protein -
EPB55_RS01470 302592..302714 - 123 WP_130195051.1 DUF3265 domain-containing protein -
EPB55_RS01475 302711..303382 - 672 WP_130195052.1 DUF4145 domain-containing protein -
EPB55_RS01480 303409..303534 - 126 WP_130195066.1 DUF3265 domain-containing protein -
EPB55_RS01485 303703..303948 - 246 WP_130195053.1 hypothetical protein -
EPB55_RS01490 303958..304068 - 111 Protein_299 DUF3265 domain-containing protein -
EPB55_RS01495 304065..304526 - 462 WP_130195054.1 GNAT family N-acetyltransferase -
EPB55_RS01500 304663..305142 - 480 WP_001100124.1 GNAT family N-acetyltransferase -
EPB55_RS01505 305286..305648 - 363 WP_011150416.1 hypothetical protein -
EPB55_RS01510 305665..305786 - 122 Protein_303 DUF3265 domain-containing protein -
EPB55_RS01515 306057..306179 - 123 WP_130195055.1 DUF3265 domain-containing protein -
EPB55_RS01520 306259..306531 + 273 WP_130195056.1 DUF1778 domain-containing protein Antitoxin
EPB55_RS01525 306528..307025 + 498 WP_130195057.1 GNAT family N-acetyltransferase Toxin
EPB55_RS01530 307059..307151 - 93 WP_005377014.1 DUF3265 domain-containing protein -
EPB55_RS01535 307166..307495 - 330 WP_130195058.1 MFS transporter permease -
EPB55_RS01540 307524..307616 - 93 WP_080640453.1 DUF3265 domain-containing protein -
EPB55_RS01545 307631..307987 - 357 WP_025630372.1 hypothetical protein -
EPB55_RS01550 308316..308708 - 393 WP_130195059.1 hypothetical protein -
EPB55_RS01555 308751..308873 - 123 Protein_312 DUF3265 domain-containing protein -
EPB55_RS01560 309218..309346 - 129 Protein_313 DUF3265 domain-containing protein -
EPB55_RS01565 309842..310237 - 396 WP_130195060.1 ACT domain-containing protein -
EPB55_RS01570 310258..310379 - 122 Protein_315 DUF3265 domain-containing protein -
EPB55_RS01575 310714..310842 - 129 WP_080933308.1 DUF3265 domain-containing protein -
EPB55_RS01580 310847..311311 - 465 WP_011080386.1 ASCH domain-containing protein -
EPB55_RS01585 311460..311915 - 456 WP_065090402.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 153034..526547 373513
- inside Integron - - 263263..314527 51264


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18489.13 Da        Isoelectric Point: 8.0487

>T118339 WP_130195057.1 NZ_CP035731:306528-307025 [Vibrio vulnificus]
MMNTVLLDKAKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNDSSHIIGFYTLTMTPIDLKSLPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFEDAENKLFITIADV
RASLG

Download         Length: 498 bp

>T118339 NZ_CP035731:306528-307025 [Vibrio vulnificus]
ATGATGAATACGGTACTTCTAGATAAAGCTAAACACGATAGAAACCGATTCAACTGTGGTATCGAAGCTCTCAATAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCAAAAAAAGACAACACCAGAACGTTTGTTTTGGAAGATGACAACGACAGCTCAC
ATATCATCGGCTTTTACACGCTAACAATGACACCAATTGACTTAAAGTCATTGCCCGATAAGTTACAAAAAAAACACCAA
TCATCCACCTCTGGTGGTCTGATTGCCCGCCTTGCTGTCGATGACCGATACAAAGGGAAAGGCTTTGGTGAGTGGCTACT
TATTGACGCACTCAGAAAGCTATTAGCTGCAAGTGATAGCGTCGCATTTCCAGTTGTTATCGTTGATGCCAAAGACGGTG
CGAAACACTTCTATGAACGCTATGGTTTTCAAGCATTTGAAGACGCTGAAAATAAACTCTTCATCACCATTGCTGATGTG
AGAGCAAGCCTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9791.33 Da        Isoelectric Point: 8.5961

>AT118339 WP_130195056.1 NZ_CP035731:306259-306531 [Vibrio vulnificus]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQTLKLSQADAMLLMEALDRPATQNSKLKA
AAERYESKIQ

Download         Length: 273 bp

>AT118339 NZ_CP035731:306259-306531 [Vibrio vulnificus]
ATGGCTACTACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACACAAGACTTACTTACTAAGGCTGCCGCGATCGC
CGGCATGTCTAGCATCAACTCGTTTGTTCTAAGCGCTGCAATCGAAAAAGCTAAACAAGTCATCGAACGTGAACAGACTT
TAAAACTGAGCCAAGCAGATGCGATGTTGCTCATGGAAGCTTTAGACCGTCCTGCAACACAGAACTCAAAACTAAAAGCT
GCGGCTGAACGATACGAGAGCAAAATTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References