Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/YafN(antitoxin)
Location 266614..267179 Replicon chromosome
Accession NZ_CP035731
Organism Vibrio vulnificus strain 2142-77

Toxin (Protein)


Gene name relE Uniprot ID A0A0H2MSY5
Locus tag EPB55_RS01135 Protein ID WP_015296903.1
Coordinates 266614..266901 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EPB55_RS01140 Protein ID WP_130194939.1
Coordinates 266898..267179 (-) Length 94 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EPB55_RS01080 262693..263090 + 398 Protein_217 transposase -
EPB55_RS01085 263091..263201 - 111 Protein_218 DUF3265 domain-containing protein -
EPB55_RS01090 263263..263493 + 231 WP_011150352.1 PAS factor family protein -
EPB55_RS23475 263561..263671 - 111 WP_165387133.1 DUF3265 domain-containing protein -
EPB55_RS01100 264022..264150 - 129 WP_130194946.1 DUF3265 domain-containing protein -
EPB55_RS01105 264165..264782 - 618 WP_065090383.1 HAD family phosphatase -
EPB55_RS01110 264798..264888 - 91 Protein_223 DUF3265 domain-containing protein -
EPB55_RS01115 264943..265212 - 270 WP_005492798.1 Txe/YoeB family addiction module toxin -
EPB55_RS01120 265205..265459 - 255 WP_005492799.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
EPB55_RS01125 265551..265673 - 123 WP_103278039.1 DUF3265 domain-containing protein -
EPB55_RS01130 266006..266134 - 129 Protein_227 DUF3265 domain-containing protein -
EPB55_RS23480 266494..266586 - 93 WP_193783921.1 DUF3265 domain-containing protein -
EPB55_RS01135 266614..266901 - 288 WP_015296903.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EPB55_RS01140 266898..267179 - 282 WP_130194939.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EPB55_RS01150 267477..268445 + 969 WP_130195236.1 IS30-like element ISVa6 family transposase -
EPB55_RS01155 268471..269286 - 816 WP_130195233.1 PhzF family phenazine biosynthesis protein -
EPB55_RS01160 269256..269345 - 90 WP_130195232.1 DUF3265 domain-containing protein -
EPB55_RS01165 269380..269781 - 402 WP_130195231.1 DUF4144 domain-containing protein -
EPB55_RS01170 269864..270241 - 378 WP_025628121.1 DUF4440 domain-containing protein -
EPB55_RS01175 270225..270404 - 180 WP_130198040.1 DUF3265 domain-containing protein -
EPB55_RS01180 270386..270817 - 432 WP_154142293.1 hypothetical protein -
EPB55_RS01185 270836..270937 - 102 WP_130195245.1 DUF3265 domain-containing protein -
EPB55_RS01190 270960..271307 - 348 WP_043920995.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 153034..526547 373513
- flank IS/Tn - - 267810..268445 635
- inside Integron - - 263263..314527 51264


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11003.69 Da        Isoelectric Point: 5.1098

>T118338 WP_015296903.1 NZ_CP035731:c266901-266614 [Vibrio vulnificus]
MKVVWSPLALQKLGDAAEFISLDNPPAAEKWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILSEDDV

Download         Length: 288 bp

>T118338 NZ_CP035731:c266901-266614 [Vibrio vulnificus]
ATGAAAGTAGTCTGGTCTCCATTAGCACTTCAGAAACTAGGTGATGCAGCGGAGTTTATTTCTTTGGATAATCCACCTGC
GGCAGAGAAGTGGGTAAACGAAGTTTTTGATAAAACTGAACTCCTTGGAAGTATGCCTGAAATGGGGCGGTTTGTTCCTG
AAATGCCCCATACGAATTATCGTGAAATCATCTTTGGTCACTATCGTATTATCTACAGTTTAAGCCACGAAATTCGCGTA
CTAACAGTTCGTAATTGTCGTCAAATTTTATCGGAAGATGACGTGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10459.00 Da        Isoelectric Point: 5.8650

>AT118338 WP_130194939.1 NZ_CP035731:c267179-266898 [Vibrio vulnificus]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVFN
DDARAQVLGRIKK

Download         Length: 282 bp

>AT118338 NZ_CP035731:c267179-266898 [Vibrio vulnificus]
ATGAGTCGTATTCATTTCGATCAAGATATTCAGCCTTTGTCTGAGTTTCGTGCCGGTGTAGCTTCATACATCAAACAAAT
CAATGAGACTCGTCGTCCATTGGTTATTACGCAACGTGGCAAAGGTGTTGCTGTTGTTCTCGATGTTGCTGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTGGAAGAAATGCGCACAGCAGAAGCTCAGTTAGCTTCTGGTCTCGGTGTTTTCAAT
GATGATGCACGTGCTCAAGTACTTGGGCGCATTAAGAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H2MSY5


Antitoxin

Source ID Structure

References