Detailed information of TA system TA118337

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 264943..265459
• Replicon: chromosome
• Accession: NZ_CP035731
• Organism: Vibrio vulnificus strain 2142-77

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EPB55_RS01115
• Protein ID: WP_005492798.1
• Coordinates: 264943..265212 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: EPB55_RS01120
• Protein ID: WP_005492799.1
• Coordinates: 265205..265459 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EPB55_RS01075	260268..262448	+	2181	WP_103277692.1	hypothetical protein	-
EPB55_RS01080	262693..263090	+	398	Protein_217	transposase	-
EPB55_RS01085	263091..263201	-	111	Protein_218	DUF3265 domain-containing protein	-
EPB55_RS01090	263263..263493	+	231	WP_011150352.1	PAS factor family protein	-
EPB55_RS23475	263561..263671	-	111	WP_165387133.1	DUF3265 domain-containing protein	-
EPB55_RS01100	264022..264150	-	129	WP_130194946.1	DUF3265 domain-containing protein	-
EPB55_RS01105	264165..264782	-	618	WP_065090383.1	HAD family phosphatase	-
EPB55_RS01110	264798..264888	-	91	Protein_223	DUF3265 domain-containing protein	-
EPB55_RS01115	264943..265212	-	270	WP_005492798.1	Txe/YoeB family addiction module toxin	Toxin
EPB55_RS01120	265205..265459	-	255	WP_005492799.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
EPB55_RS01125	265551..265673	-	123	WP_103278039.1	DUF3265 domain-containing protein	-
EPB55_RS01130	266006..266134	-	129	Protein_227	DUF3265 domain-containing protein	-
EPB55_RS23480	266494..266586	-	93	WP_193783921.1	DUF3265 domain-containing protein	-
EPB55_RS01135	266614..266901	-	288	WP_015296903.1	type II toxin-antitoxin system RelE/ParE family toxin	-
EPB55_RS01140	266898..267179	-	282	WP_130194939.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
EPB55_RS01150	267477..268445	+	969	WP_130195236.1	IS30-like element ISVa6 family transposase	-
EPB55_RS01155	268471..269286	-	816	WP_130195233.1	PhzF family phenazine biosynthesis protein	-
EPB55_RS01160	269256..269345	-	90	WP_130195232.1	DUF3265 domain-containing protein	-
EPB55_RS01165	269380..269781	-	402	WP_130195231.1	DUF4144 domain-containing protein	-
EPB55_RS01170	269864..270241	-	378	WP_025628121.1	DUF4440 domain-containing protein	-
EPB55_RS01175	270225..270404	-	180	WP_130198040.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	153034..526547	373513
	-	flank	IS/Tn	-	-	267810..268445	635
	-	inside	Integron	-	-	263263..314527	51264

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10557.95 Da
• Isoelectric Point: 8.8578

>T118337 WP_005492798.1 NZ_CP035731:c265212-264943 [Vibrio vulnificus]
MSSSQRLLSWTDDAWSDYLYWQTQDKKTLKRINKLITDVKRSPFEGIGKPEPLKENLAGFWSRRIDDTNRLVYAVDDQAL
TIISCRYHY

Nucleotide

• Length: 270 bp

>T118337 NZ_CP035731:c265212-264943 [Vibrio vulnificus]
ATGAGTAGTAGTCAACGTTTACTATCTTGGACTGACGATGCTTGGAGTGATTATTTGTACTGGCAAACCCAAGACAAGAA
AACTTTAAAACGAATCAATAAGCTAATTACTGACGTTAAACGTTCTCCTTTTGAGGGCATAGGTAAACCAGAGCCATTAA
AAGAAAACCTAGCTGGTTTTTGGTCACGCCGTATTGATGACACTAATAGACTTGTCTATGCCGTTGATGATCAGGCACTC
ACGATAATTTCGTGTCGCTACCACTACTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9498.68 Da
• Isoelectric Point: 5.1007

>AT118337 WP_005492799.1 NZ_CP035731:c265459-265205 [Vibrio vulnificus]
MRIVSFTEARNSLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPENAEHLKRSIAQYRAGKTTARE
LIDE

Nucleotide

• Length: 255 bp

>AT118337 NZ_CP035731:c265459-265205 [Vibrio vulnificus]
ATGAGAATCGTATCTTTTACAGAAGCTAGAAATAGTCTCAAAGCGGTTTTAGATGGTGTCGTCAATGATGCAGACACAAC
CGTTATTACTCGTCGTGATTCGGAAGATGCAGTGGTTATGTCCCTAGACTATTACAATAGTCTTATGGAGACCGTTCATT
TACTTCGCTCTCCTGAAAATGCTGAGCATTTAAAACGTTCGATAGCCCAGTATCGTGCTGGTAAAACTACAGCACGAGAA
TTAATCGATGAGTAG