Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2229913..2230447 Replicon chromosome
Accession NZ_CP035730
Organism Sulfolobus sp. S-194

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EWF20_RS11740 Protein ID WP_168065965.1
Coordinates 2230127..2230447 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EWF20_RS11735 Protein ID WP_168065963.1
Coordinates 2229913..2230137 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EWF20_RS11715 (EWF20_11620) 2226345..2226773 - 429 WP_168065955.1 Zn-ribbon domain-containing OB-fold protein -
EWF20_RS11720 (EWF20_11625) 2226770..2227267 - 498 WP_168065957.1 Zn-ribbon domain-containing OB-fold protein -
EWF20_RS11725 (EWF20_11630) 2227279..2228454 - 1176 WP_168065959.1 thiolase domain-containing protein -
EWF20_RS11730 (EWF20_11635) 2228454..2229563 - 1110 WP_168065961.1 thiolase domain-containing protein -
EWF20_RS11735 (EWF20_11640) 2229913..2230137 + 225 WP_168065963.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
EWF20_RS11740 (EWF20_11645) 2230127..2230447 + 321 WP_168065965.1 PIN domain nuclease Toxin
EWF20_RS11745 (EWF20_11650) 2230651..2231781 - 1131 WP_168066999.1 acyl-CoA dehydrogenase family protein -
EWF20_RS11750 (EWF20_11655) 2231849..2233714 + 1866 WP_168065967.1 AMP-binding protein -
EWF20_RS11755 (EWF20_11660) 2233711..2234526 + 816 WP_168065968.1 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Post-segregation antitoxin CcdA

(5-53)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12387.47 Da        Isoelectric Point: 4.8010

>T118336 WP_168065965.1 NZ_CP035730:2230127-2230447 [Sulfolobus sp. S-194]
MRDEFLLDASALYPILSYIDKIDVTKIYVIPLTFYKVGNAIWKEYYLKNKDPITLCALFQKFMSKLKLLDNPPAEEIMRV
TSEKELTFYDATYVYSAESYGLFLVS

Download         Length: 321 bp

>T118336 NZ_CP035730:2230127-2230447 [Sulfolobus sp. S-194]
ATGAGAGATGAGTTTTTATTAGATGCCTCAGCATTATACCCTATACTTAGCTACATAGATAAGATAGACGTTACTAAGAT
TTATGTAATTCCTTTGACCTTTTACAAAGTTGGAAACGCAATATGGAAGGAATATTATCTGAAAAATAAGGATCCAATCA
CATTATGTGCTCTCTTTCAGAAGTTTATGAGTAAACTTAAACTCCTTGACAATCCACCAGCTGAGGAAATAATGAGAGTT
ACATCAGAAAAAGAACTGACTTTTTACGATGCTACGTACGTTTATTCTGCTGAATCCTATGGGCTATTTTTAGTCTCATA
A

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8928.23 Da        Isoelectric Point: 4.5901

>AT118336 WP_168065963.1 NZ_CP035730:2229913-2230137 [Sulfolobus sp. S-194]
MSTIISVRVRQELKEKAEKLGINIREVVERALEEAIKEKENEEIEETVRKIKELMKDISEDEWIALIREDRYER

Download         Length: 225 bp

>AT118336 NZ_CP035730:2229913-2230137 [Sulfolobus sp. S-194]
ATGTCAACCATAATAAGTGTAAGAGTGAGGCAGGAGTTGAAAGAAAAAGCTGAGAAATTGGGAATTAACATTAGGGAAGT
TGTAGAGAGGGCTTTAGAGGAGGCAATAAAAGAGAAAGAAAATGAGGAGATTGAGGAAACCGTTAGAAAAATTAAGGAAT
TAATGAAGGATATTAGTGAGGATGAATGGATTGCCTTAATAAGGGAAGATAGATATGAGAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References