Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 531084..531688 Replicon chromosome
Accession NZ_CP035708
Organism Sphaerotilus natans subsp. sulfidivorans strain D-507

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EWH46_RS02605 Protein ID WP_149502531.1
Coordinates 531509..531688 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EWH46_RS02600 Protein ID WP_149502530.1
Coordinates 531084..531497 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EWH46_RS02570 527361..527741 + 381 WP_149502525.1 transposase -
EWH46_RS02575 527757..528677 - 921 WP_149502526.1 hypothetical protein -
EWH46_RS02580 528692..528871 - 180 WP_149502527.1 hypothetical protein -
EWH46_RS02585 528868..529872 - 1005 WP_149502528.1 plasmid recombination protein -
EWH46_RS02590 529869..530066 - 198 WP_149505130.1 hypothetical protein -
EWH46_RS02595 530223..530990 - 768 WP_149502529.1 hypothetical protein -
EWH46_RS02600 531084..531497 - 414 WP_149502530.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EWH46_RS02605 531509..531688 - 180 WP_149502531.1 type II toxin-antitoxin system HicA family toxin Toxin
EWH46_RS02610 531726..532364 - 639 WP_149502532.1 tyrosine-type recombinase/integrase -
EWH46_RS02615 532701..533927 - 1227 WP_149502533.1 type II secretion system F family protein -
EWH46_RS02620 534016..535809 - 1794 WP_149502534.1 type IV-A pilus assembly ATPase PilB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6473.61 Da        Isoelectric Point: 11.9313

>T118296 WP_149502531.1 NZ_CP035708:c531688-531509 [Sphaerotilus natans subsp. sulfidivorans]
MTSADLIRDLRRAGWALDRVAGSHHIFKHPSRPGIVVVPHPKKDLGIGLVKSIRQQAGI

Download         Length: 180 bp

>T118296 NZ_CP035708:c531688-531509 [Sphaerotilus natans subsp. sulfidivorans]
ATGACGAGTGCCGACCTGATCCGTGACCTGCGGCGTGCTGGCTGGGCGCTTGACCGCGTGGCGGGTTCACATCACATCTT
CAAGCATCCCAGCCGGCCCGGAATCGTTGTCGTGCCGCACCCGAAGAAGGATTTGGGCATCGGCCTTGTGAAGTCCATCC
GGCAACAGGCCGGCATCTGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 14945.06 Da        Isoelectric Point: 4.3741

>AT118296 WP_149502530.1 NZ_CP035708:c531497-531084 [Sphaerotilus natans subsp. sulfidivorans]
MRYPIAIEPGTDTTAWGVVVPDLPGCFSAGDTLEEAMIQAEEAITAWVEVAIDSGESIPKPSPLETLRTAHPEFEGWVWA
LVKVDPAMLDETVERVNISLPRRVLHRLDDLARRAGETRSGFIARMAIEGRAPVAPA

Download         Length: 414 bp

>AT118296 NZ_CP035708:c531497-531084 [Sphaerotilus natans subsp. sulfidivorans]
ATGCGCTATCCCATTGCCATCGAACCCGGCACCGACACGACCGCGTGGGGTGTCGTGGTGCCGGACCTGCCGGGCTGCTT
CTCTGCGGGCGACACGCTGGAAGAGGCCATGATTCAAGCCGAAGAGGCCATCACGGCATGGGTGGAGGTCGCGATTGACT
CGGGCGAGAGCATCCCGAAGCCGTCCCCCCTGGAGACTCTGCGCACCGCACATCCCGAGTTTGAAGGCTGGGTGTGGGCG
CTGGTGAAGGTGGACCCCGCCATGCTGGACGAGACGGTGGAGCGGGTGAACATCAGCCTGCCGCGCCGCGTGCTGCACCG
CCTGGACGACTTGGCCCGCCGGGCTGGTGAAACCCGGTCTGGCTTCATCGCCCGGATGGCCATCGAGGGGCGCGCACCGG
TAGCGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References