Detailed information of TA system TA118294

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2811909..2812761
• Replicon: chromosome
• Accession: NZ_CP035704
• Organism: Pseudolysobacter antarcticus strain AQ6-296

Toxin (Protein)

• Gene name: HipA3
• Uniprot ID: -
• Locus tag: ELE36_RS11995
• Protein ID: WP_129833595.1
• Coordinates: 2811909..2812274 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: HipB3
• Uniprot ID: -
• Locus tag: ELE36_RS12000
• Protein ID: WP_129833597.1
• Coordinates: 2812408..2812761 (-)
• Length: 118 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ELE36_RS11965	2807339..2808511	-	1173	WP_129833585.1	hypothetical protein	-
ELE36_RS11970	2808624..2808941	+	318	WP_207215945.1	YkgJ family cysteine cluster protein	-
ELE36_RS11975	2808946..2809194	+	249	WP_129833587.1	GIY-YIG nuclease family protein	-
ELE36_RS11980	2809300..2809758	+	459	WP_129833589.1	tryptophan-rich sensory protein	-
ELE36_RS11985	2809780..2810847	-	1068	WP_129833591.1	sensor domain-containing diguanylate cyclase	-
ELE36_RS11990	2811138..2811857	+	720	WP_129833593.1	hypothetical protein	-
ELE36_RS11995	2811909..2812274	-	366	WP_129833595.1	HipA domain-containing protein	Toxin
ELE36_RS12000	2812408..2812761	-	354	WP_129833597.1	helix-turn-helix domain-containing protein	Antitoxin
ELE36_RS20375	2812934..2813125	-	192	WP_165371396.1	hypothetical protein	-
ELE36_RS12005	2813419..2814096	+	678	WP_129833599.1	sce7726 family protein	-
ELE36_RS12010	2814093..2815172	-	1080	WP_165371584.1	beta family protein	-
ELE36_RS12015	2815184..2815687	-	504	WP_129833603.1	ImmA/IrrE family metallo-endopeptidase	-
ELE36_RS12020	2815684..2816160	-	477	WP_129833605.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (1-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (17-69)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 13581.55 Da
• Isoelectric Point: 10.4494

>T118294 WP_129833595.1 NZ_CP035704:c2812274-2811909 [Pseudolysobacter antarcticus]
MVFNIVARNQDDHVKNIAFLMNQRGEWTLAPAFDVTYSYNPSGAWTATHQMTLNGKRDGFTMADVAACAKAAVIKRGRAA
IIINEVPAAVRRWPEFAAAARLVDEWRSKIQHTHRLTFPQA

Nucleotide

• Length: 366 bp

>T118294 NZ_CP035704:c2812274-2811909 [Pseudolysobacter antarcticus]
ATGGTTTTCAACATCGTGGCGCGGAACCAGGACGATCACGTCAAGAACATTGCTTTCCTGATGAACCAGCGAGGTGAGTG
GACGCTCGCGCCGGCGTTCGATGTGACCTATAGCTATAACCCGTCCGGCGCGTGGACAGCGACGCACCAGATGACGTTGA
ACGGGAAACGGGACGGCTTCACGATGGCGGACGTTGCAGCCTGCGCGAAAGCGGCGGTGATCAAGCGCGGGCGAGCGGCG
ATCATCATCAATGAAGTGCCGGCGGCGGTGCGGCGCTGGCCGGAGTTTGCCGCCGCCGCGCGGCTGGTCGACGAATGGCG
CAGCAAGATTCAACACACCCACCGGCTGACTTTTCCTCAAGCATAA

Antitoxin

Protein

• Length: 118 a.a.
• Molecular weight: 13046.25 Da
• Isoelectric Point: 11.5297

>AT118294 WP_129833597.1 NZ_CP035704:c2812761-2812408 [Pseudolysobacter antarcticus]
MKIESQLTDEVLLKLTGERLARLRLSKNLTQEQLAQQAGLGLRTVQRLELGVAATRLSGFLRVCRVLGLAERFAALVPEQ
TASPMELLKQQGRKRQRASGKPAATRKPKAWTWGEPE

Nucleotide

• Length: 354 bp

>AT118294 NZ_CP035704:c2812761-2812408 [Pseudolysobacter antarcticus]
ATGAAGATCGAATCCCAGCTAACCGATGAGGTGTTGCTCAAGTTGACGGGCGAGCGTCTGGCCCGATTGCGCTTGAGCAA
GAACCTTACGCAGGAGCAACTCGCGCAGCAGGCGGGTCTGGGCTTGCGGACCGTGCAACGGCTCGAACTGGGAGTGGCTG
CGACCCGGCTTTCGGGTTTTCTGCGCGTGTGCCGGGTGCTGGGTCTGGCAGAGCGGTTTGCGGCACTAGTTCCCGAGCAG
ACGGCCAGTCCGATGGAGCTACTGAAGCAGCAAGGCCGCAAGCGGCAGCGTGCCAGTGGCAAACCGGCGGCGACGAGAAA
GCCGAAGGCGTGGACGTGGGGCGAGCCCGAATGA