Detailed information of TA system TA118292

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 267598..268262
• Replicon: chromosome
• Accession: NZ_CP035704
• Organism: Pseudolysobacter antarcticus strain AQ6-296

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: ELE36_RS01175
• Protein ID: WP_165371420.1
• Coordinates: 267598..268017 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: ELE36_RS01180
• Protein ID: WP_129831360.1
• Coordinates: 268014..268262 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ELE36_RS01155	262986..264302	-	1317	WP_129831355.1	TolC family protein	-
ELE36_RS01160	264387..264773	-	387	WP_129831356.1	hypothetical protein	-
ELE36_RS01165	264835..266169	-	1335	WP_129831357.1	histidine kinase	-
ELE36_RS01170	266222..267601	-	1380	WP_129831358.1	sigma-54 dependent transcriptional regulator	-
ELE36_RS01175	267598..268017	-	420	WP_165371420.1	type II toxin-antitoxin system VapC family toxin	Toxin
ELE36_RS01180	268014..268262	-	249	WP_129831360.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ELE36_RS01185	268298..268969	-	672	WP_129831361.1	ABC transporter ATP-binding protein	-
ELE36_RS01190	268994..271420	-	2427	WP_129831362.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-128)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-65)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15578.07 Da
• Isoelectric Point: 8.0521

>T118292 WP_165371420.1 NZ_CP035704:c268017-267598 [Pseudolysobacter antarcticus]
VSYLLDTCVLSEYTQLVPDPKVLAWIDSIAETRLYVSALSLGEIRQGAAHIANTKKSARLMEWLELQLLPRFEHRVLSVD
TEIALVWGELRGSLLRKGKPASLFDSLIAATAKVHGFSVVTRNVRDFKNFEVGIINPWS

Nucleotide

• Length: 420 bp

>T118292 NZ_CP035704:c268017-267598 [Pseudolysobacter antarcticus]
GTGAGTTATTTGCTCGACACCTGCGTGCTTTCCGAATACACGCAACTGGTCCCCGACCCCAAGGTTCTTGCGTGGATCGA
CAGTATTGCCGAAACCCGGTTATACGTCAGCGCGCTCAGTCTCGGTGAAATTCGACAGGGCGCCGCACATATAGCCAACA
CCAAAAAATCCGCGCGCCTGATGGAATGGCTGGAGTTGCAACTGCTGCCGCGCTTTGAACATCGCGTGTTGTCCGTTGAC
ACCGAAATCGCCTTGGTATGGGGAGAATTGCGTGGCTCCTTGCTACGCAAGGGCAAACCCGCCTCCTTGTTTGATTCGTT
GATTGCGGCTACTGCAAAAGTTCACGGATTCAGCGTCGTTACGCGTAATGTGCGTGACTTCAAAAACTTCGAGGTCGGCA
TCATCAACCCATGGTCATGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9169.46 Da
• Isoelectric Point: 10.0022

>AT118292 WP_129831360.1 NZ_CP035704:c268262-268014 [Pseudolysobacter antarcticus]
MNWQLQEAKNRLSEVVKAAEKKGPQVITVRGKETAVVISMGTYKKMSGSSQSLSEFLSNSPLKGLELEQRNPRDTEYRDV
GL

Nucleotide

• Length: 249 bp

>AT118292 NZ_CP035704:c268262-268014 [Pseudolysobacter antarcticus]
ATGAATTGGCAACTTCAGGAAGCGAAAAATCGATTGAGCGAAGTGGTGAAGGCTGCGGAAAAAAAAGGCCCGCAGGTGAT
TACCGTACGTGGCAAGGAAACGGCTGTAGTCATTTCCATGGGGACGTACAAAAAAATGTCCGGCAGCTCGCAGAGCTTGT
CCGAGTTCCTCAGTAATTCGCCATTGAAGGGATTGGAACTCGAACAGCGTAATCCGCGCGACACCGAATACCGGGACGTC
GGCCTGTGA