Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 544606..545144 Replicon chromosome
Accession NZ_CP035698
Organism Vibrio cincinnatiensis strain 2409-02

Toxin (Protein)


Gene name parE Uniprot ID A0A0N8UHD2
Locus tag ET948_RS15730 Protein ID WP_000802131.1
Coordinates 544845..545144 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0Q0JMN6
Locus tag ET948_RS15725 Protein ID WP_002044787.1
Coordinates 544606..544848 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ET948_RS15690 539892..540251 - 360 WP_154116433.1 VOC family protein -
ET948_RS15695 540908..541753 - 846 WP_154116435.1 hypothetical protein -
ET948_RS15700 541895..542431 - 537 WP_154116437.1 hypothetical protein -
ET948_RS15705 542483..542599 - 117 WP_154116927.1 DUF3265 domain-containing protein -
ET948_RS15710 542662..543060 - 399 WP_078927613.1 aegerolysin family protein -
ET948_RS15715 543405..543665 - 261 WP_154116439.1 DUF3709 domain-containing protein -
ET948_RS15720 543940..544311 - 372 WP_154116929.1 CPBP family intramembrane metalloprotease -
ET948_RS15725 544606..544848 + 243 WP_002044787.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
ET948_RS15730 544845..545144 + 300 WP_000802131.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ET948_RS15735 545781..546173 - 393 WP_154116282.1 nuclear transport factor 2 family protein -
ET948_RS15740 546326..546829 - 504 WP_000734953.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 518073..571302 53229


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11607.26 Da        Isoelectric Point: 9.9232

>T118287 WP_000802131.1 NZ_CP035698:544845-545144 [Vibrio cincinnatiensis]
MKPFNLTTAAKTDLRDIALFTQRRWGKEQRNIYLKQFDDSFWLLAENPDIGKSCDEIRDGYRKFPQGSHVIFYQQTGSQQ
IRVVRILHKSMDVNPIFGA

Download         Length: 300 bp

>T118287 NZ_CP035698:544845-545144 [Vibrio cincinnatiensis]
ATGAAACCATTTAATCTTACAACTGCAGCCAAAACCGATTTGCGTGATATCGCTTTATTTACTCAACGCCGTTGGGGCAA
AGAGCAGCGAAACATCTACTTAAAGCAATTTGACGATTCATTTTGGCTTTTGGCTGAAAATCCCGACATCGGCAAATCAT
GTGATGAAATTCGAGATGGTTACCGTAAATTCCCTCAAGGTAGCCATGTGATTTTTTATCAGCAAACGGGCAGCCAACAG
ATTAGAGTCGTCCGTATTTTACATAAGAGTATGGATGTTAATCCGATCTTTGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8979.81 Da        Isoelectric Point: 4.1677

>AT118287 WP_002044787.1 NZ_CP035698:544606-544848 [Vibrio cincinnatiensis]
MAKNTSITLGEHFDGFITNQIQSGRYGSASEVIRSALRLLENQETKLQTLRQLLVEGEQSGDADYDLDSFINELDSETNR

Download         Length: 243 bp

>AT118287 NZ_CP035698:544606-544848 [Vibrio cincinnatiensis]
ATGGCTAAGAACACAAGTATTACCCTTGGTGAACACTTTGATGGTTTTATTACAAACCAAATTCAAAGTGGGCGTTATGG
CTCTGCAAGTGAAGTTATTCGCTCAGCTTTGCGTTTACTCGAAAACCAAGAGACTAAACTGCAGACTCTCCGTCAACTAC
TGGTTGAAGGTGAACAAAGTGGTGACGCTGATTATGACCTTGATAGTTTCATCAATGAACTTGATAGTGAAACTAATCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N8UHD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q0JMN6

References