Detailed information of TA system TA118286

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 520809..521374
• Replicon: chromosome
• Accession: NZ_CP035698
• Organism: Vibrio cincinnatiensis strain 2409-02

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ET948_RS15510
• Protein ID: WP_154116254.1
• Coordinates: 520809..521096 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: W9USL4
• Locus tag: ET948_RS15515
• Protein ID: WP_000086650.1
• Coordinates: 521093..521374 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ET948_RS15480	516573..517760	-	1188	WP_154116383.1	site-specific integrase	-
ET948_RS15485	518073..518339	-	267	WP_154116385.1	hypothetical protein	-
ET948_RS15490	518836..518949	-	114	WP_154116922.1	DUF3265 domain-containing protein	-
ET948_RS15495	518955..519584	-	630	WP_154116387.1	FMN-binding negative transcriptional regulator	-
ET948_RS15500	519726..520142	-	417	WP_154116389.1	VOC family protein	-
ET948_RS15505	520689..520799	-	111	WP_154116889.1	DUF3265 domain-containing protein	-
ET948_RS15510	520809..521096	-	288	WP_154116254.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ET948_RS15515	521093..521374	-	282	WP_000086650.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ET948_RS15520	521574..522128	-	555	WP_154116391.1	hypothetical protein	-
ET948_RS15525	522675..522788	-	114	WP_154116922.1	DUF3265 domain-containing protein	-
ET948_RS15530	522794..523423	-	630	WP_154116387.1	FMN-binding negative transcriptional regulator	-
ET948_RS15535	523582..523974	-	393	WP_154116282.1	nuclear transport factor 2 family protein	-
ET948_RS15540	524013..524123	-	111	WP_154116918.1	DUF3265 domain-containing protein	-
ET948_RS15545	524179..524469	-	291	WP_154116395.1	hypothetical protein	-
ET948_RS15550	525586..525978	-	393	WP_154116397.1	nuclear transport factor 2 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	518073..571302	53229

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10943.74 Da
• Isoelectric Point: 5.6096

>T118286 WP_154116254.1 NZ_CP035698:c521096-520809 [Vibrio cincinnatiensis]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELIGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLGLEIRV
LTVRNCRQLLTEHDV

Nucleotide

• Length: 288 bp

>T118286 NZ_CP035698:c521096-520809 [Vibrio cincinnatiensis]
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTTGGTGATGCTGCAGAGTTTATTGCTTTGGATAACCCCTCAGC
TGCAGAAAAGTGGGTGAATGAAGTGTTCGACAAAACGGAATTGATCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATAATTTTTGGCCATTACCGTATTATTTATAGTTTGGGCCTCGAAATACGTGTT
CTAACAGTCCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10347.90 Da
• Isoelectric Point: 5.1548

>AT118286 WP_000086650.1 NZ_CP035698:c521374-521093 [Vibrio cincinnatiensis]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGVSN
EDARSQVLGRIIK

Nucleotide

• Length: 282 bp

>AT118286 NZ_CP035698:c521374-521093 [Vibrio cincinnatiensis]
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAAACTCGTCGACCATTAGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTTGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTGGGTGTATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGACGCATCATCAAATGA

Structures

Antitoxin

• AlphaFold DB: W9USL4