Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 477731..478281 Replicon chromosome
Accession NZ_CP035698
Organism Vibrio cincinnatiensis strain 2409-02

Toxin (Protein)


Gene name parE Uniprot ID A0A1T4SPA2
Locus tag ET948_RS15245 Protein ID WP_039428516.1
Coordinates 477982..478281 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A099LYH9
Locus tag ET948_RS15240 Protein ID WP_039428513.1
Coordinates 477731..477973 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ET948_RS15220 475176..476300 + 1125 WP_154116312.1 ISAs1 family transposase -
ET948_RS15225 476435..476527 - 93 WP_081302018.1 DUF3265 domain-containing protein -
ET948_RS15230 476542..477015 - 474 WP_154116328.1 hypothetical protein -
ET948_RS15235 477525..477620 - 96 Protein_442 DUF3265 domain-containing protein -
ET948_RS15240 477731..477973 + 243 WP_039428513.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ET948_RS15245 477982..478281 + 300 WP_039428516.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ET948_RS15250 478327..478452 - 126 WP_080289624.1 DUF3265 domain-containing protein -
ET948_RS15255 478917..479489 - 573 WP_154116330.1 hypothetical protein -
ET948_RS15260 480140..480598 - 459 WP_065818886.1 hypothetical protein -
ET948_RS15265 480649..481500 - 852 WP_158147655.1 IS3 family transposase -
ET948_RS15270 481584..481805 - 222 Protein_449 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 436106..502859 66753


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-56)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11622.26 Da        Isoelectric Point: 9.6429

>T118285 WP_039428516.1 NZ_CP035698:477982-478281 [Vibrio cincinnatiensis]
MHNKQYKLSSLAQTHLRKVKNYTINNFSELQWQRYKETLLSGFQMLADNPDLGRSCHEIYSNGFYFPIGKHTAYFTKEEN
FILIVAVLGQSQLPQNHLK

Download         Length: 300 bp

>T118285 NZ_CP035698:477982-478281 [Vibrio cincinnatiensis]
ATGCACAATAAACAATATAAACTGAGTAGTTTGGCTCAAACTCATTTACGTAAAGTAAAAAATTATACCATCAACAATTT
TTCCGAATTACAGTGGCAACGTTATAAAGAAACACTACTTTCTGGCTTTCAAATGCTCGCTGATAATCCTGATTTAGGAC
GAAGCTGCCATGAAATATATAGTAACGGCTTTTACTTTCCGATTGGAAAACACACTGCTTACTTCACAAAGGAAGAGAAT
TTCATCTTAATCGTAGCTGTATTGGGGCAATCTCAGTTACCGCAAAATCACCTGAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9164.51 Da        Isoelectric Point: 5.6772

>AT118285 WP_039428513.1 NZ_CP035698:477731-477973 [Vibrio cincinnatiensis]
MYTLTANDAKRNFGELLLNAQRQPIKISKNSKDAVVVMSIHDYEELEMMKTEYLKHCFNVAKDDLAKGNVVDGKDFLNEL

Download         Length: 243 bp

>AT118285 NZ_CP035698:477731-477973 [Vibrio cincinnatiensis]
ATGTATACATTAACAGCAAATGACGCTAAACGAAATTTTGGTGAATTGCTTCTTAATGCTCAACGCCAACCAATTAAGAT
CAGTAAAAACAGCAAAGATGCTGTTGTCGTGATGTCTATACATGACTACGAAGAGCTTGAAATGATGAAAACAGAATATC
TTAAACATTGTTTCAACGTGGCTAAAGATGACTTGGCAAAAGGCAATGTCGTTGATGGTAAAGATTTTTTGAATGAGCTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1T4SPA2

Antitoxin

Source ID Structure
AlphaFold DB A0A099LYH9

References