Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 461024..461595 Replicon chromosome
Accession NZ_CP035698
Organism Vibrio cincinnatiensis strain 2409-02

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag ET948_RS15135 Protein ID WP_000351248.1
Coordinates 461024..461425 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag ET948_RS15140 Protein ID WP_001080654.1
Coordinates 461425..461595 (-) Length 57 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ET948_RS15100 456094..456528 - 435 WP_154116308.1 hypothetical protein -
ET948_RS15105 456660..457124 - 465 WP_154116310.1 hypothetical protein -
ET948_RS15110 457196..458320 - 1125 WP_154116312.1 ISAs1 family transposase -
ET948_RS15115 459127..459423 - 297 WP_053339486.1 PQQ-binding-like beta-propeller repeat protein -
ET948_RS15120 460210..460524 - 315 WP_000071008.1 DNA-binding transcriptional regulator -
ET948_RS15125 460511..460843 - 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin -
ET948_RS15130 460911..461054 - 144 WP_195707336.1 DUF3265 domain-containing protein -
ET948_RS15135 461024..461425 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
ET948_RS15140 461425..461595 - 171 WP_001080654.1 hypothetical protein Antitoxin
ET948_RS15145 461775..463082 - 1308 WP_154116314.1 DUF3644 domain-containing protein -
ET948_RS15150 463232..463591 - 360 WP_154116316.1 hypothetical protein -
ET948_RS15155 463638..463754 - 117 Protein_426 DUF3265 domain-containing protein -
ET948_RS15160 463751..464146 - 396 WP_154116906.1 hypothetical protein -
ET948_RS17655 465598..466554 + 957 WP_195707319.1 IS110 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 384751..459423 74672
- flank IS/Tn - - 465598..466554 956
- inside Integron - - 436106..502859 66753


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-132)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T118284 WP_000351248.1 NZ_CP035698:c461425-461024 [Vibrio cincinnatiensis]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T118284 NZ_CP035698:c461425-461024 [Vibrio cincinnatiensis]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAAATTAATGCTTTCATCCTAAAAACGGAACCTGGAATGAAAGG
AGCAGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAGTACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGGACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT118284 WP_001080654.1 NZ_CP035698:c461595-461425 [Vibrio cincinnatiensis]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT118284 NZ_CP035698:c461595-461425 [Vibrio cincinnatiensis]
ATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGTTGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGAC
AGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTAAACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGG
CTGATATGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0Q0PN34


Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SJJ1

References