Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | phd-doc/Doc(toxin) |
Location | 461024..461595 | Replicon | chromosome |
Accession | NZ_CP035698 | ||
Organism | Vibrio cincinnatiensis strain 2409-02 |
Toxin (Protein)
Gene name | doc | Uniprot ID | Q9KMA2 |
Locus tag | ET948_RS15135 | Protein ID | WP_000351248.1 |
Coordinates | 461024..461425 (-) | Length | 134 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | Q8GNG3 |
Locus tag | ET948_RS15140 | Protein ID | WP_001080654.1 |
Coordinates | 461425..461595 (-) | Length | 57 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ET948_RS15100 | 456094..456528 | - | 435 | WP_154116308.1 | hypothetical protein | - |
ET948_RS15105 | 456660..457124 | - | 465 | WP_154116310.1 | hypothetical protein | - |
ET948_RS15110 | 457196..458320 | - | 1125 | WP_154116312.1 | ISAs1 family transposase | - |
ET948_RS15115 | 459127..459423 | - | 297 | WP_053339486.1 | PQQ-binding-like beta-propeller repeat protein | - |
ET948_RS15120 | 460210..460524 | - | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | - |
ET948_RS15125 | 460511..460843 | - | 333 | WP_000843587.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
ET948_RS15130 | 460911..461054 | - | 144 | WP_195707336.1 | DUF3265 domain-containing protein | - |
ET948_RS15135 | 461024..461425 | - | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
ET948_RS15140 | 461425..461595 | - | 171 | WP_001080654.1 | hypothetical protein | Antitoxin |
ET948_RS15145 | 461775..463082 | - | 1308 | WP_154116314.1 | DUF3644 domain-containing protein | - |
ET948_RS15150 | 463232..463591 | - | 360 | WP_154116316.1 | hypothetical protein | - |
ET948_RS15155 | 463638..463754 | - | 117 | Protein_426 | DUF3265 domain-containing protein | - |
ET948_RS15160 | 463751..464146 | - | 396 | WP_154116906.1 | hypothetical protein | - |
ET948_RS17655 | 465598..466554 | + | 957 | WP_195707319.1 | IS110 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 384751..459423 | 74672 | |
- | flank | IS/Tn | - | - | 465598..466554 | 956 | |
- | inside | Integron | - | - | 436106..502859 | 66753 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14608.71 Da Isoelectric Point: 4.0128
>T118284 WP_000351248.1 NZ_CP035698:c461425-461024 [Vibrio cincinnatiensis]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL
Download Length: 402 bp
>T118284 NZ_CP035698:c461425-461024 [Vibrio cincinnatiensis]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAAATTAATGCTTTCATCCTAAAAACGGAACCTGGAATGAAAGG
AGCAGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAGTACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGGACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAAATTAATGCTTTCATCCTAAAAACGGAACCTGGAATGAAAGG
AGCAGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAGTACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGGACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6287.35 Da Isoelectric Point: 10.7274
>AT118284 WP_001080654.1 NZ_CP035698:c461595-461425 [Vibrio cincinnatiensis]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM
Download Length: 171 bp
>AT118284 NZ_CP035698:c461595-461425 [Vibrio cincinnatiensis]
ATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGTTGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGAC
AGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTAAACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGG
CTGATATGTAA
ATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGTTGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGAC
AGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTAAACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGG
CTGATATGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0Q0PN34 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1T4SJJ1 |