Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 393171..393937 Replicon chromosome
Accession NZ_CP035698
Organism Vibrio cincinnatiensis strain 2409-02

Toxin (Protein)


Gene name - Uniprot ID A0A6G3L8F0
Locus tag ET948_RS14695 Protein ID WP_010319335.1
Coordinates 393440..393937 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID C9P137
Locus tag ET948_RS14690 Protein ID WP_004394087.1
Coordinates 393171..393443 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ET948_RS14640 388206..388490 + 285 WP_154116224.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
ET948_RS14645 388487..388765 + 279 WP_045569735.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
ET948_RS14650 388914..389543 - 630 WP_154116226.1 FMN-binding negative transcriptional regulator -
ET948_RS14655 389572..389685 - 114 Protein_326 DUF3265 domain-containing protein -
ET948_RS14660 389686..390150 - 465 WP_154116228.1 ASCH domain-containing protein -
ET948_RS14665 390304..390918 - 615 WP_154116229.1 outer membrane beta-barrel protein -
ET948_RS14670 391005..391856 - 852 WP_158147655.1 IS3 family transposase -
ET948_RS14675 391940..392161 - 222 Protein_330 transposase -
ET948_RS14680 392321..392935 - 615 WP_154116231.1 hypothetical protein -
ET948_RS14685 392970..393131 - 162 WP_154116881.1 DUF3265 domain-containing protein -
ET948_RS14690 393171..393443 + 273 WP_004394087.1 DUF1778 domain-containing protein Antitoxin
ET948_RS14695 393440..393937 + 498 WP_010319335.1 GNAT family N-acetyltransferase Toxin
ET948_RS14700 394921..395043 - 123 Protein_335 DUF3265 domain-containing protein -
ET948_RS14705 395154..396002 - 849 WP_154116233.1 lipase family protein -
ET948_RS14710 396187..397311 + 1125 WP_154116235.1 ISAs1 family transposase -
ET948_RS14715 397308..397493 - 186 WP_154116238.1 hypothetical protein -
ET948_RS14720 397625..397756 - 132 WP_154116883.1 DUF3265 domain-containing protein -
ET948_RS14725 398061..398696 - 636 WP_154116239.1 hypothetical protein -
ET948_RS14730 398834..398923 - 90 WP_154116241.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 384751..459423 74672
- inside Integron - - 387209..409983 22774


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18577.41 Da        Isoelectric Point: 9.5688

>T118280 WP_010319335.1 NZ_CP035698:393440-393937 [Vibrio cincinnatiensis]
MMKTVLLDKDKHDRNRFNCGIDALNNYLKVMASQQAKKDNTRTFVLEDENNTSLIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAIDERYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFKAFQDAENKLFITISDI
RASLG

Download         Length: 498 bp

>T118280 NZ_CP035698:393440-393937 [Vibrio cincinnatiensis]
ATGATGAAAACGGTATTGCTCGATAAAGATAAACACGATAGAAACCGATTCAACTGCGGAATTGATGCGCTTAATAACTA
TTTGAAAGTAATGGCAAGTCAGCAAGCTAAAAAAGACAATACCCGAACATTTGTTTTAGAGGATGAAAATAACACCTCAC
TTATCATCGGTTTTTACACTTTAACAATGACACCCATTGACCTAAAAGCATTACCCGATAAGTTACAGAAAAAGCATCAG
TCATCAACGTCTGGCGGACTCATTGCTCGCTTAGCTATCGATGAGCGCTATAAAGGCAAAGGATTTGGCGAGTGGTTACT
TATCGATGCTCTACGAAAACTACTAGCCGCTAGTGATAGCGTGGCATTCCCAGTCGTTATTGTTGACGCAAAAGATGGCG
CTAAACATTTCTATGAACGCTATGGTTTTAAGGCATTTCAAGATGCAGAAAATAAGCTATTTATCACCATTTCAGATATT
AGGGCAAGTTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9872.43 Da        Isoelectric Point: 9.7681

>AT118280 WP_004394087.1 NZ_CP035698:393171-393443 [Vibrio cincinnatiensis]
MATTLPRITARVDVDTQNLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQTLKLSQADAILLMEALDKPTTLNQKLKT
AAERYETKNQ

Download         Length: 273 bp

>AT118280 NZ_CP035698:393171-393443 [Vibrio cincinnatiensis]
ATGGCTACCACTTTACCTCGTATCACTGCGAGAGTTGATGTTGATACACAAAACTTATTAACCAAAGCGGCTGCTCTCGC
TGGCATGTCTAGTATTAACTCATTTGTACTCAATGCTGCAATCGAAAAAGCAAAACAAGTGATTGAACGTGAGCAAACAC
TAAAATTAAGCCAAGCAGACGCCATTTTACTTATGGAAGCTCTCGATAAACCAACAACATTAAATCAAAAGCTTAAAACT
GCCGCCGAACGCTATGAGACCAAAAACCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G3L8F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SI33

References