Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-Phd |
| Location | 386919..387466 | Replicon | chromosome |
| Accession | NZ_CP035698 | ||
| Organism | Vibrio cincinnatiensis strain 2409-02 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A223N2K4 |
| Locus tag | ET948_RS14625 | Protein ID | WP_000229324.1 |
| Coordinates | 386919..387221 (-) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9KM93 |
| Locus tag | ET948_RS14630 | Protein ID | WP_000861987.1 |
| Coordinates | 387209..387466 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ET948_RS14600 | 383018..383776 | + | 759 | WP_154116218.1 | molybdopterin-synthase adenylyltransferase MoeB | - |
| ET948_RS14605 | 383848..384675 | + | 828 | WP_154116220.1 | sulfurtransferase | - |
| ET948_RS14610 | 384751..385332 | - | 582 | WP_154116222.1 | DUF1287 domain-containing protein | - |
| ET948_RS14615 | 385370..386422 | - | 1053 | WP_195707330.1 | ISAs1 family transposase | - |
| ET948_RS14620 | 386793..386909 | - | 117 | Protein_319 | DUF3265 domain-containing protein | - |
| ET948_RS14625 | 386919..387221 | - | 303 | WP_000229324.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| ET948_RS14630 | 387209..387466 | - | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| ET948_RS14635 | 388040..388150 | - | 111 | Protein_322 | DUF3265 domain-containing protein | - |
| ET948_RS14640 | 388206..388490 | + | 285 | WP_154116224.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| ET948_RS14645 | 388487..388765 | + | 279 | WP_045569735.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| ET948_RS14650 | 388914..389543 | - | 630 | WP_154116226.1 | FMN-binding negative transcriptional regulator | - |
| ET948_RS14655 | 389572..389685 | - | 114 | Protein_326 | DUF3265 domain-containing protein | - |
| ET948_RS14660 | 389686..390150 | - | 465 | WP_154116228.1 | ASCH domain-containing protein | - |
| ET948_RS14665 | 390304..390918 | - | 615 | WP_154116229.1 | outer membrane beta-barrel protein | - |
| ET948_RS14670 | 391005..391856 | - | 852 | WP_158147655.1 | IS3 family transposase | - |
| ET948_RS14675 | 391940..392161 | - | 222 | Protein_330 | transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 384751..459423 | 74672 | |
| - | inside | Integron | - | - | 387209..409983 | 22774 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11795.70 Da Isoelectric Point: 4.9166
>T118278 WP_000229324.1 NZ_CP035698:c387221-386919 [Vibrio cincinnatiensis]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDEKV
RILFVMRAERDLRRLMLTKQ
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDEKV
RILFVMRAERDLRRLMLTKQ
Download Length: 303 bp
>T118278 NZ_CP035698:c387221-386919 [Vibrio cincinnatiensis]
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGATCTGAACGATATTGCTGAATACATCGCACTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCAC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAATCCATGTCGTGTTTTCTACAAGTATGATGATGAAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTAACGAAACAGTAG
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGATCTGAACGATATTGCTGAATACATCGCACTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCAC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAATCCATGTCGTGTTTTCTACAAGTATGATGATGAAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTAACGAAACAGTAG
Antitoxin
Download Length: 86 a.a. Molecular weight: 9647.15 Da Isoelectric Point: 7.3178
>AT118278 WP_000861987.1 NZ_CP035698:c387466-387209 [Vibrio cincinnatiensis]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
Download Length: 258 bp
>AT118278 NZ_CP035698:c387466-387209 [Vibrio cincinnatiensis]
ATGAAAGTAGAACTCGTGACGTCACTAAAACGGCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAGCCGTCAGCTTACCTTATTGATGTAGATGATTATGAATTTATGCAAAATCGTTTAGCGA
TCCTCGAAGGCATTGCTCGTGGCGAACGAGCTCTAGCGGATGGCAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA
ATGAAAGTAGAACTCGTGACGTCACTAAAACGGCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAGCCGTCAGCTTACCTTATTGATGTAGATGATTATGAATTTATGCAAAATCGTTTAGCGA
TCCTCGAAGGCATTGCTCGTGGCGAACGAGCTCTAGCGGATGGCAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A223N2K4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1T4SLM9 |