Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 2685648..2686207 Replicon chromosome
Accession NZ_CP035693
Organism Vibrio harveyi strain 2011V-1164

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR22
Locus tag EPB58_RS22955 Protein ID WP_005398411.1
Coordinates 2685648..2685926 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag EPB58_RS22960 Protein ID WP_005398409.1
Coordinates 2685923..2686207 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EPB58_RS22895 2680662..2681219 + 558 WP_050925170.1 hypothetical protein -
EPB58_RS22900 2681234..2681326 + 93 WP_140372744.1 DUF3265 domain-containing protein -
EPB58_RS22910 2681815..2681946 + 132 WP_154203591.1 DUF3265 domain-containing protein -
EPB58_RS22915 2681983..2682741 + 759 WP_154203592.1 hypothetical protein -
EPB58_RS22920 2682756..2682848 + 93 WP_154203593.1 DUF3265 domain-containing protein -
EPB58_RS22925 2683509..2683778 + 270 WP_154203594.1 DUF1778 domain-containing protein -
EPB58_RS22930 2683775..2684308 + 534 WP_154203595.1 GNAT family N-acetyltransferase -
EPB58_RS22935 2684336..2684428 + 93 WP_140050421.1 DUF3265 domain-containing protein -
EPB58_RS22940 2684457..2684984 + 528 WP_045491262.1 CbrC family protein -
EPB58_RS26690 2685005..2685097 + 93 WP_004748931.1 DUF3265 domain-containing protein -
EPB58_RS22950 2685135..2685512 + 378 WP_025769014.1 hypothetical protein -
EPB58_RS22955 2685648..2685926 - 279 WP_005398411.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
EPB58_RS22960 2685923..2686207 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EPB58_RS22965 2686284..2686418 + 135 WP_154203596.1 DUF3265 domain-containing protein -
EPB58_RS26755 2686485..2686757 + 273 WP_206666881.1 hypothetical protein -
EPB58_RS26760 2686754..2686987 + 234 WP_202801021.1 hypothetical protein -
EPB58_RS22975 2687364..2688107 + 744 WP_154203597.1 hypothetical protein -
EPB58_RS22980 2688202..2688696 + 495 WP_154203598.1 hypothetical protein -
EPB58_RS22985 2688855..2689382 + 528 WP_130193141.1 hypothetical protein -
EPB58_RS22990 2689409..2689501 + 93 WP_193222943.1 DUF3265 domain-containing protein -
EPB58_RS22995 2689530..2689748 + 219 Protein_2413 hypothetical protein -
EPB58_RS26695 2689773..2689864 + 92 Protein_2414 DUF3265 domain-containing protein -
EPB58_RS23000 2689927..2690439 + 513 WP_053306500.1 hypothetical protein -
EPB58_RS23005 2690452..2690592 - 141 WP_154203600.1 hypothetical protein -
EPB58_RS23010 2690699..2690875 + 177 WP_154203601.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2626626..2701535 74909
- inside Integron - - 2625357..2695931 70574


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10891.57 Da        Isoelectric Point: 4.3430

>T118276 WP_005398411.1 NZ_CP035693:c2685926-2685648 [Vibrio harveyi]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T118276 NZ_CP035693:c2685926-2685648 [Vibrio harveyi]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTCTCTTATTGGGTCGAGGGCGATATCATCAGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT118276 WP_005398409.1 NZ_CP035693:c2686207-2685923 [Vibrio harveyi]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT118276 NZ_CP035693:c2686207-2685923 [Vibrio harveyi]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGTCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTGTTTTCGTTGAGCACCAAACTGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR22

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References