Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 2683509..2684308 Replicon chromosome
Accession NZ_CP035693
Organism Vibrio harveyi strain 2011V-1164

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag EPB58_RS22930 Protein ID WP_154203595.1
Coordinates 2683775..2684308 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag EPB58_RS22925 Protein ID WP_154203594.1
Coordinates 2683509..2683778 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EPB58_RS22860 2678737..2678826 + 90 WP_195724152.1 DUF3265 domain-containing protein -
EPB58_RS22865 2678856..2679440 + 585 WP_025553754.1 hypothetical protein -
EPB58_RS22870 2679462..2679554 + 93 WP_080251722.1 DUF3265 domain-containing protein -
EPB58_RS22875 2679587..2679931 + 345 WP_154203588.1 hypothetical protein -
EPB58_RS22880 2679946..2680038 + 93 WP_079749986.1 DUF3265 domain-containing protein -
EPB58_RS22885 2680077..2680514 + 438 WP_154203589.1 hypothetical protein -
EPB58_RS22890 2680541..2680633 + 93 WP_118781066.1 DUF3265 domain-containing protein -
EPB58_RS22895 2680662..2681219 + 558 WP_050925170.1 hypothetical protein -
EPB58_RS22900 2681234..2681326 + 93 WP_140372744.1 DUF3265 domain-containing protein -
EPB58_RS22910 2681815..2681946 + 132 WP_154203591.1 DUF3265 domain-containing protein -
EPB58_RS22915 2681983..2682741 + 759 WP_154203592.1 hypothetical protein -
EPB58_RS22920 2682756..2682848 + 93 WP_154203593.1 DUF3265 domain-containing protein -
EPB58_RS22925 2683509..2683778 + 270 WP_154203594.1 DUF1778 domain-containing protein Antitoxin
EPB58_RS22930 2683775..2684308 + 534 WP_154203595.1 GNAT family N-acetyltransferase Toxin
EPB58_RS22935 2684336..2684428 + 93 WP_140050421.1 DUF3265 domain-containing protein -
EPB58_RS22940 2684457..2684984 + 528 WP_045491262.1 CbrC family protein -
EPB58_RS26690 2685005..2685097 + 93 WP_004748931.1 DUF3265 domain-containing protein -
EPB58_RS22950 2685135..2685512 + 378 WP_025769014.1 hypothetical protein -
EPB58_RS22955 2685648..2685926 - 279 WP_005398411.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
EPB58_RS22960 2685923..2686207 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
EPB58_RS22965 2686284..2686418 + 135 WP_154203596.1 DUF3265 domain-containing protein -
EPB58_RS26755 2686485..2686757 + 273 WP_206666881.1 hypothetical protein -
EPB58_RS26760 2686754..2686987 + 234 WP_202801021.1 hypothetical protein -
EPB58_RS22975 2687364..2688107 + 744 WP_154203597.1 hypothetical protein -
EPB58_RS22980 2688202..2688696 + 495 WP_154203598.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2626626..2701535 74909
- inside Integron - - 2625357..2695931 70574


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20135.49 Da        Isoelectric Point: 9.6702

>T118275 WP_154203595.1 NZ_CP035693:2683775-2684308 [Vibrio harveyi]
VSWGKEFVELSKSKHDRNSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAQPMLNQKFAICAFYSVAPSSISRETLPV
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNG
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T118275 NZ_CP035693:2683775-2684308 [Vibrio harveyi]
GTGAGTTGGGGTAAAGAGTTCGTAGAACTGAGTAAATCAAAGCATGACCGCAACTCATTTGATTGTGGTGAGCAAGAATT
AAACACATTTATCAAGACTCAAGCAGCAAAGCACATGCAAGCAGGCATTAGCCGAACAATGGTTTTACCTAGTGCTCAAC
CAATGCTCAATCAAAAGTTCGCTATTTGTGCATTTTATAGTGTTGCCCCGAGCTCTATCAGCCGAGAAACATTACCAGTA
CAACTAGCAAAGAAGCTTCCTAGATATCCAATCCCAGTTTTTCTTTTGGCTCAATTAGCGGTGCACAAAGAGTTTCATGG
CTCTGGACTCGGAAAGGTTAGTCTTATTCGTGCCCTGAAATACTTATGGGAAGTAAATCATCACATGCGGGCATACGCAA
TTGTGGTGGACTGTCTTACCGATTCTGCTCAAGCGTTCTATACGAAGTTTGGCTTTGAAGTATTGTGTGAACATAATGGA
CGTATTCGTATGTTCTTACCAATGAAAACGGTAGAACAGCTGTTTAATCAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9871.30 Da        Isoelectric Point: 4.5716

>AT118275 WP_154203594.1 NZ_CP035693:2683509-2683778 [Vibrio harveyi]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKTKAPNQALLDAA
KFTDESGIK

Download         Length: 270 bp

>AT118275 NZ_CP035693:2683509-2683778 [Vibrio harveyi]
ATGGCAACTGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCCGAAAAAGCATCGGCTTTACTTGGTTT
AAAAAGTCTTACTGAATATGTTGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAAGAGCATGAAAGTATTATGG
TCAAAGACAGTGTCTTTGACGAGTTTATGGCTGCGTGTAATAAAACGAAAGCTCCGAATCAAGCTTTGCTTGATGCTGCC
AAATTTACAGATGAGAGTGGCATTAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References