Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 2662075..2662620 Replicon chromosome
Accession NZ_CP035693
Organism Vibrio harveyi strain 2011V-1164

Toxin (Protein)


Gene name parE Uniprot ID A0A0C1WCQ3
Locus tag EPB58_RS22665 Protein ID WP_020197846.1
Coordinates 2662075..2662371 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0C1VVX7
Locus tag EPB58_RS22670 Protein ID WP_020197845.1
Coordinates 2662378..2662620 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EPB58_RS22615 2657345..2657437 + 93 WP_195724108.1 DUF3265 domain-containing protein -
EPB58_RS22620 2658036..2658563 - 528 WP_206666879.1 hypothetical protein -
EPB58_RS22625 2658791..2658901 + 111 WP_080375476.1 DUF3265 domain-containing protein -
EPB58_RS22630 2659180..2659338 + 159 WP_154203573.1 DUF3265 domain-containing protein -
EPB58_RS22640 2659985..2660497 + 513 WP_154203574.1 GNAT family N-acetyltransferase -
EPB58_RS22645 2660512..2660604 + 93 WP_195724109.1 DUF3265 domain-containing protein -
EPB58_RS22650 2661059..2661151 + 93 WP_154203575.1 DUF3265 domain-containing protein -
EPB58_RS22655 2661220..2661906 + 687 WP_154203576.1 HNH endonuclease -
EPB58_RS22660 2661924..2662013 + 90 WP_080265160.1 DUF3265 domain-containing protein -
EPB58_RS22665 2662075..2662371 - 297 WP_020197846.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EPB58_RS22670 2662378..2662620 - 243 WP_020197845.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EPB58_RS22680 2662910..2663167 + 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
EPB58_RS22685 2663155..2663457 + 303 WP_010448451.1 type II toxin-antitoxin system RelE/ParE family toxin -
EPB58_RS22690 2663493..2663585 + 93 WP_005445734.1 DUF3265 domain-containing protein -
EPB58_RS22695 2663623..2664498 + 876 WP_154203837.1 restriction endonuclease -
EPB58_RS22700 2664685..2665008 - 324 WP_154203578.1 hypothetical protein -
EPB58_RS22705 2665095..2665226 + 132 WP_154203579.1 DUF3265 domain-containing protein -
EPB58_RS22710 2665317..2665595 + 279 WP_038886177.1 hypothetical protein -
EPB58_RS22715 2665613..2665702 + 90 WP_071881309.1 DUF3265 domain-containing protein -
EPB58_RS22720 2665741..2666271 + 531 WP_140376626.1 hypothetical protein -
EPB58_RS22725 2666286..2666378 + 93 WP_193241297.1 DUF3265 domain-containing protein -
EPB58_RS22730 2666359..2666976 + 618 WP_154203580.1 YdcF family protein -
EPB58_RS22735 2666991..2667083 + 93 WP_140069081.1 DUF3265 domain-containing protein -
EPB58_RS22740 2667110..2667520 + 411 WP_154203838.1 hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2626626..2701535 74909
- inside Integron - - 2625357..2695931 70574


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-63)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11248.91 Da        Isoelectric Point: 9.6269

>T118273 WP_020197846.1 NZ_CP035693:c2662371-2662075 [Vibrio harveyi]
MQKNKYKLSKLAQAHLRKIKSYTINNFSEMQWNNYKDTLLAGFQMLADNPAVGRSCDEIYPSSFYFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL

Download         Length: 297 bp

>T118273 NZ_CP035693:c2662371-2662075 [Vibrio harveyi]
ATGCAAAAGAATAAATACAAACTAAGTAAATTGGCTCAGGCTCATTTACGAAAAATTAAAAGCTATACCATCAACAACTT
TTCTGAAATGCAGTGGAACAACTATAAAGATACATTGCTAGCTGGGTTTCAAATGCTTGCCGACAACCCAGCCGTAGGTC
GCAGCTGTGACGAGATTTATCCAAGCAGTTTCTATTTTCCGGTAGGAAAACACACAGCTTACTTTACAAAGGAAGACGGT
TTTATTTTAGTTGTGGCTGTACTTGGTCAATCGCAACTCCCACAAAACCACTTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8977.16 Da        Isoelectric Point: 4.7914

>AT118273 WP_020197845.1 NZ_CP035693:c2662620-2662378 [Vibrio harveyi]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLKHCFESAKQDLAQGNVVDGEDFLSTL

Download         Length: 243 bp

>AT118273 NZ_CP035693:c2662620-2662378 [Vibrio harveyi]
ATGCACACACTAACAGCAAATGATGCAAAGCGTAACTTTGGTGAGCTCCTTCTAAGCGCCCAACGTGAGCCAGTAAAGAT
TAGCAAAAACAGTAAAGATGCCGTGGTGGTAATGTCTATCAAAGACTATGAAGAACTAGAGGCAATGAAAACTGATTACC
TTAAACATTGTTTCGAGTCAGCTAAACAAGACTTAGCACAAGGCAATGTTGTTGATGGGGAAGATTTCCTAAGCACCTTG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C1WCQ3

Antitoxin

Source ID Structure
AlphaFold DB A0A0C1VVX7

References