Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 2648499..2649058 Replicon chromosome
Accession NZ_CP035693
Organism Vibrio harveyi strain 2011V-1164

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EPB58_RS22515 Protein ID WP_154203559.1
Coordinates 2648499..2648777 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EPB58_RS22520 Protein ID WP_154203560.1
Coordinates 2648777..2649058 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EPB58_RS22470 2643602..2643694 + 93 WP_079859306.1 DUF3265 domain-containing protein -
EPB58_RS22475 2643740..2644222 + 483 WP_154203555.1 hypothetical protein -
EPB58_RS22480 2644246..2644338 + 93 WP_195724149.1 DUF3265 domain-containing protein -
EPB58_RS22485 2644885..2645289 + 405 WP_080544944.1 SH3 domain-containing protein -
EPB58_RS22490 2645321..2645413 + 93 WP_017420683.1 DUF3265 domain-containing protein -
EPB58_RS22495 2645889..2645981 + 93 WP_193261311.1 DUF3265 domain-containing protein -
EPB58_RS22500 2646624..2646716 + 93 WP_080257495.1 DUF3265 domain-containing protein -
EPB58_RS22505 2646744..2647319 + 576 WP_154203558.1 hypothetical protein -
EPB58_RS22510 2647548..2647790 + 243 WP_004418123.1 hypothetical protein -
EPB58_RS22515 2648499..2648777 - 279 WP_154203559.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EPB58_RS22520 2648777..2649058 - 282 WP_154203560.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EPB58_RS22525 2649135..2649242 + 108 WP_154203561.1 DUF3265 domain-containing protein -
EPB58_RS22530 2649253..2650272 + 1020 WP_154203562.1 hypothetical protein -
EPB58_RS22535 2650411..2651040 + 630 WP_154203563.1 RusA family crossover junction endodeoxyribonuclease -
EPB58_RS22540 2651045..2651155 + 111 WP_195724150.1 DUF3265 domain-containing protein -
EPB58_RS22545 2651183..2651629 + 447 WP_154203565.1 GyrI-like domain-containing protein -
EPB58_RS22550 2651746..2652519 + 774 WP_154203566.1 hypothetical protein -
EPB58_RS22555 2652625..2652948 + 324 WP_077200549.1 hypothetical protein -
EPB58_RS22560 2652977..2653066 + 90 WP_154203567.1 hypothetical protein -
EPB58_RS22565 2653088..2653927 + 840 WP_154203568.1 hypothetical protein -
EPB58_RS22570 2653942..2654035 + 94 Protein_2331 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2626626..2701535 74909
- inside Integron - - 2625357..2695931 70574


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10891.62 Da        Isoelectric Point: 4.4558

>T118272 WP_154203559.1 NZ_CP035693:c2648777-2648499 [Vibrio harveyi]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVKRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T118272 NZ_CP035693:c2648777-2648499 [Vibrio harveyi]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTGATGGGTGTAAAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTCTCTTACTGGGTCGAGGGCGATATCATCAGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10941.27 Da        Isoelectric Point: 9.2167

>AT118272 WP_154203560.1 NZ_CP035693:c2649058-2648777 [Vibrio harveyi]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGK

Download         Length: 282 bp

>AT118272 NZ_CP035693:c2649058-2648777 [Vibrio harveyi]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGAAC
TCTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTGTTTTCGTTGAGCACCAAACTGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References