Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 689080..689608 Replicon chromosome
Accession NZ_CP035691
Organism Grimontia hollisae strain 2013V-1029

Toxin (Protein)


Gene name relE Uniprot ID D0I5S7
Locus tag ET950_RS18380 Protein ID WP_005502664.1
Coordinates 689080..689370 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A377J6M1
Locus tag ET950_RS18385 Protein ID WP_040528287.1
Coordinates 689360..689608 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ET950_RS18360 685345..686289 - 945 WP_154124967.1 ribosome biogenesis GTPase YlqF -
ET950_RS18365 686459..687292 - 834 WP_005502668.1 EAL domain-containing protein -
ET950_RS18370 687752..688543 + 792 WP_005502667.1 phenylalanine 4-monooxygenase -
ET950_RS18375 688554..688895 + 342 WP_005502665.1 4a-hydroxytetrahydrobiopterin dehydratase -
ET950_RS18380 689080..689370 - 291 WP_005502664.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ET950_RS18385 689360..689608 - 249 WP_040528287.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ET950_RS18390 689974..691272 + 1299 WP_005502662.1 urea ABC transporter substrate-binding protein -
ET950_RS18395 691426..693075 + 1650 WP_154124968.1 urea ABC transporter permease subunit UrtB -
ET950_RS18400 693076..694158 + 1083 WP_195714660.1 urea ABC transporter permease subunit UrtC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11257.22 Da        Isoelectric Point: 10.5943

>T118271 WP_005502664.1 NZ_CP035691:c689370-689080 [Grimontia hollisae]
MTYKLSFKKSALKEWKKLGSTLQQQFKKKLIERLENPHVPASKLSGVDNMYKIKLRQSGYRLVYKVEDDVIVVTVLAVGK
RERSDVYHKAMKRQDD

Download         Length: 291 bp

>T118271 NZ_CP035691:c689370-689080 [Grimontia hollisae]
ATGACCTATAAACTCAGCTTTAAAAAGAGCGCGCTCAAAGAGTGGAAAAAGCTTGGTTCAACGCTGCAACAACAGTTTAA
GAAGAAGCTAATTGAACGCCTGGAAAATCCGCATGTTCCAGCTTCAAAGCTTTCTGGCGTTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGTTACCGCCTCGTCTACAAAGTTGAAGACGATGTCATCGTTGTCACCGTCTTAGCAGTCGGAAAA
CGCGAACGTAGCGATGTTTACCATAAGGCTATGAAAAGGCAAGATGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9021.33 Da        Isoelectric Point: 3.9610

>AT118271 WP_040528287.1 NZ_CP035691:c689608-689360 [Grimontia hollisae]
MTARILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDKLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT118271 NZ_CP035691:c689608-689360 [Grimontia hollisae]
ATGACCGCTAGAATTTTAGCCGATGTGGCTGCAAGCATTACAGAATTGAAAGCTAACCCTATGAAAGTTGCAACCAGTGC
TTATGGCGAACCTGTTGCTGTACTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAAACTCGAAGATCTTGAGCTGCTTGCAATTGCTAAAGAGCGTGAATCTGAAGAGAGTATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D0I5S7

Antitoxin

Source ID Structure
AlphaFold DB A0A377J6M1

References