Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 833755..834314 Replicon chromosome
Accession NZ_CP035690
Organism Grimontia hollisae strain 2013V-1029

Toxin (Protein)


Gene name relE Uniprot ID D0I9X2
Locus tag ET950_RS03835 Protein ID WP_005505046.1
Coordinates 833755..834033 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag ET950_RS03840 Protein ID WP_005398409.1
Coordinates 834030..834314 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ET950_RS03815 829169..830190 - 1022 Protein_728 IS110 family transposase -
ET950_RS03820 830286..830849 + 564 WP_143692585.1 hypothetical protein -
ET950_RS03825 831307..832350 - 1044 WP_154124099.1 IS110 family transposase -
ET950_RS03830 832764..833663 - 900 WP_154124194.1 IS110 family transposase -
ET950_RS03835 833755..834033 - 279 WP_005505046.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
ET950_RS03840 834030..834314 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ET950_RS03845 834390..834494 + 105 WP_192940932.1 DUF3265 domain-containing protein -
ET950_RS03850 834513..834947 + 435 WP_050778565.1 hypothetical protein -
ET950_RS03855 835223..835522 - 300 WP_114995249.1 type II toxin-antitoxin system RelE/ParE family toxin -
ET950_RS03860 835519..835764 - 246 WP_154124195.1 type II toxin-antitoxin system ParD family antitoxin -
ET950_RS03865 835921..836460 + 540 WP_154124196.1 isochorismatase family protein -
ET950_RS03870 836578..838011 - 1434 WP_154124197.1 amino acid permease -
ET950_RS03875 838089..838541 - 453 WP_154124198.1 beta-galactosidase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(1-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10910.62 Da        Isoelectric Point: 4.3430

>T118269 WP_005505046.1 NZ_CP035690:c834033-833755 [Grimontia hollisae]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDYLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPAD

Download         Length: 279 bp

>T118269 NZ_CP035690:c834033-833755 [Grimontia hollisae]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAGACTGACTACCTCATTGAAGCCAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTCTCTTACTGGGTCGAAGGCGATATCATCCGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTGCGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT118269 WP_005398409.1 NZ_CP035690:c834314-834030 [Grimontia hollisae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT118269 NZ_CP035690:c834314-834030 [Grimontia hollisae]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACTGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377HNB0

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References