Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 564179..564726 Replicon chromosome
Accession NZ_CP035689
Organism Vibrio metoecus strain 08-2459

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EWA65_RS16195 Protein ID WP_154139265.1
Coordinates 564179..564481 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag EWA65_RS16200 Protein ID WP_000861987.1
Coordinates 564469..564726 (-) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EWA65_RS16140 559538..559659 - 122 Protein_571 DUF3265 domain-containing protein -
EWA65_RS16145 560007..560117 - 111 WP_086017781.1 DUF3265 domain-containing protein -
EWA65_RS16150 560584..560898 - 315 WP_000071008.1 DNA-binding transcriptional regulator -
EWA65_RS16155 560885..561217 - 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin -
EWA65_RS16160 561407..561844 - 438 WP_055028344.1 NUDIX pyrophosphatase -
EWA65_RS16165 562007..562222 - 216 WP_154139263.1 DUF645 family protein -
EWA65_RS16175 562651..562911 - 261 WP_162807037.1 DUF3709 domain-containing protein -
EWA65_RS16180 562881..563030 - 150 Protein_578 DUF3709 domain-containing protein -
EWA65_RS16185 563030..563170 - 141 WP_195708057.1 DUF3265 domain-containing protein -
EWA65_RS16190 563686..563874 - 189 Protein_580 DUF645 family protein -
EWA65_RS16195 564179..564481 - 303 WP_154139265.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EWA65_RS16200 564469..564726 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EWA65_RS16205 564917..565276 - 360 WP_055028343.1 VOC family protein -
EWA65_RS16215 565429..565815 - 387 WP_055028342.1 MmcQ/YjbR family DNA-binding protein -
EWA65_RS16220 565957..566349 - 393 WP_095457973.1 nuclear transport factor 2 family protein -
EWA65_RS16225 566546..566728 - 183 WP_009355233.1 DUF645 family protein -
EWA65_RS16230 567032..567955 - 924 Protein_587 arginase family protein -
EWA65_RS16235 568126..568392 - 267 WP_043993103.1 hypothetical protein -
EWA65_RS16240 568614..569129 - 516 WP_114808324.1 lipocalin family protein -
EWA65_RS18880 569325..569421 - 97 Protein_590 DUF645 family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 453640..607302 153662
- inside Integrative and Conjugative Element - hlyA 504927..845208 340281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 101 a.a.        Molecular weight: 11684.62 Da        Isoelectric Point: 4.8837

>T118265 WP_154139265.1 NZ_CP035689:c564481-564179 [Vibrio metoecus]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVECLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T118265 NZ_CP035689:c564481-564179 [Vibrio metoecus]
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAATGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAATCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT118265 WP_000861987.1 NZ_CP035689:c564726-564469 [Vibrio metoecus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT118265 NZ_CP035689:c564726-564469 [Vibrio metoecus]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCTGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References