Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 496347..496906 Replicon chromosome
Accession NZ_CP035689
Organism Vibrio metoecus strain 08-2459

Toxin (Protein)


Gene name relE Uniprot ID A0A0Q0N9E9
Locus tag EWA65_RS15525 Protein ID WP_000578475.1
Coordinates 496628..496906 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag EWA65_RS15520 Protein ID WP_000381183.1
Coordinates 496347..496631 (+) Length 95 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EWA65_RS15475 491387..491671 - 285 WP_055028441.1 antibiotic biosynthesis monooxygenase -
EWA65_RS15480 491959..492194 + 236 Protein_452 RNA-binding protein -
EWA65_RS15485 492383..492772 - 390 WP_055052207.1 VOC family protein -
EWA65_RS15490 492977..493558 - 582 WP_175242889.1 nucleotidyltransferase family protein -
EWA65_RS15495 493707..493991 + 285 WP_000381185.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
EWA65_RS15500 493988..494266 + 279 WP_055028440.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
EWA65_RS15505 494433..494981 - 549 WP_095459700.1 hypothetical protein -
EWA65_RS15510 495324..495788 + 465 WP_055028448.1 hypothetical protein -
EWA65_RS15515 495861..496142 - 282 WP_000382665.1 hypothetical protein -
EWA65_RS18860 496142..496231 - 90 WP_195708051.1 acetyltransferase -
EWA65_RS15520 496347..496631 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EWA65_RS15525 496628..496906 + 279 WP_000578475.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
EWA65_RS15530 497065..497331 - 267 WP_043993103.1 hypothetical protein -
EWA65_RS15535 497558..497947 - 390 WP_055028449.1 VOC family protein -
EWA65_RS15540 498616..499131 - 516 WP_055028451.1 hypothetical protein -
EWA65_RS15545 499326..499979 - 654 WP_055028465.1 M23 family metallopeptidase -
EWA65_RS15550 500140..500616 - 477 WP_055028466.1 DUF2059 domain-containing protein -
EWA65_RS15555 500796..501200 - 405 WP_154139238.1 MAPEG family protein -
EWA65_RS15560 501379..501792 - 414 WP_154139239.1 GNAT family N-acetyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 453640..607302 153662


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10824.53 Da        Isoelectric Point: 4.6794

>T118262 WP_000578475.1 NZ_CP035689:496628-496906 [Vibrio metoecus]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDEVIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T118262 NZ_CP035689:496628-496906 [Vibrio metoecus]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCCGC
TGAAAAAACGGACGAGGTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATGGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATCGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT118262 WP_000381183.1 NZ_CP035689:496347-496631 [Vibrio metoecus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT118262 NZ_CP035689:496347-496631 [Vibrio metoecus]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGTCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0Q0N9E9


Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References