Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 493707..494266 Replicon chromosome
Accession NZ_CP035689
Organism Vibrio metoecus strain 08-2459

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EWA65_RS15500 Protein ID WP_055028440.1
Coordinates 493988..494266 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0N8UHC9
Locus tag EWA65_RS15495 Protein ID WP_000381185.1
Coordinates 493707..493991 (+) Length 95 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EWA65_RS15450 488752..488881 - 130 Protein_446 DUF645 family protein -
EWA65_RS15455 489281..489460 - 180 WP_154139237.1 DUF645 family protein -
EWA65_RS15460 489762..490202 - 441 WP_033933262.1 hypothetical protein -
EWA65_RS15465 490236..490346 - 111 WP_154139386.1 DUF3265 domain-containing protein -
EWA65_RS15470 490349..491251 - 903 WP_055028442.1 hypothetical protein -
EWA65_RS15475 491387..491671 - 285 WP_055028441.1 antibiotic biosynthesis monooxygenase -
EWA65_RS15480 491959..492194 + 236 Protein_452 RNA-binding protein -
EWA65_RS15485 492383..492772 - 390 WP_055052207.1 VOC family protein -
EWA65_RS15490 492977..493558 - 582 WP_175242889.1 nucleotidyltransferase family protein -
EWA65_RS15495 493707..493991 + 285 WP_000381185.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EWA65_RS15500 493988..494266 + 279 WP_055028440.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
EWA65_RS15505 494433..494981 - 549 WP_095459700.1 hypothetical protein -
EWA65_RS15510 495324..495788 + 465 WP_055028448.1 hypothetical protein -
EWA65_RS15515 495861..496142 - 282 WP_000382665.1 hypothetical protein -
EWA65_RS18860 496142..496231 - 90 WP_195708051.1 acetyltransferase -
EWA65_RS15520 496347..496631 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
EWA65_RS15525 496628..496906 + 279 WP_000578475.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
EWA65_RS15530 497065..497331 - 267 WP_043993103.1 hypothetical protein -
EWA65_RS15535 497558..497947 - 390 WP_055028449.1 VOC family protein -
EWA65_RS15540 498616..499131 - 516 WP_055028451.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 453640..607302 153662


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10895.66 Da        Isoelectric Point: 4.8605

>T118261 WP_055028440.1 NZ_CP035689:493988-494266 [Vibrio metoecus]
MIFWEEASLNDREKIFEFLYDFNPVAAEKTDELIETKVENLLEQPLMGVQRNGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T118261 NZ_CP035689:493988-494266 [Vibrio metoecus]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTTTACGACTTTAACCCAGTAGCAGC
TGAAAAAACGGATGAGCTCATAGAAACCAAAGTTGAAAATTTGCTTGAGCAACCACTAATGGGTGTTCAGCGTAATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10887.22 Da        Isoelectric Point: 8.0775

>AT118261 WP_000381185.1 NZ_CP035689:493707-493991 [Vibrio metoecus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFVEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT118261 NZ_CP035689:493707-493991 [Vibrio metoecus]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCGGTATTCGTTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0N8UHC9

References