Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 1047546..1048084 | Replicon | chromosome |
| Accession | NZ_CP035687 | ||
| Organism | Vibrio metoecus strain 2011V-1169 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | EPB59_RS18120 | Protein ID | WP_000802134.1 |
| Coordinates | 1047546..1047845 (-) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A271VK51 |
| Locus tag | EPB59_RS18125 | Protein ID | WP_001107720.1 |
| Coordinates | 1047842..1048084 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EPB59_RS18055 | 1043181..1043624 | + | 444 | WP_154174221.1 | hypothetical protein | - |
| EPB59_RS18065 | 1043772..1044239 | + | 468 | WP_000702485.1 | GNAT family N-acetyltransferase | - |
| EPB59_RS18070 | 1044329..1044516 | + | 188 | Protein_938 | DUF3709 domain-containing protein | - |
| EPB59_RS18075 | 1044513..1044688 | + | 176 | Protein_939 | DUF3709 domain-containing protein | - |
| EPB59_RS18080 | 1045175..1045354 | + | 180 | WP_029628718.1 | DUF645 family protein | - |
| EPB59_RS18085 | 1045531..1045848 | - | 318 | WP_000077449.1 | CcdB family protein | - |
| EPB59_RS18090 | 1045848..1046093 | - | 246 | WP_001260801.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| EPB59_RS18095 | 1046214..1046429 | + | 216 | WP_154173277.1 | DUF3709 domain-containing protein | - |
| EPB59_RS18100 | 1046441..1046572 | + | 132 | WP_001886409.1 | DUF3709 domain-containing protein | - |
| EPB59_RS18105 | 1046585..1046659 | + | 75 | WP_108244119.1 | hypothetical protein | - |
| EPB59_RS18110 | 1046881..1047042 | + | 162 | Protein_946 | DUF3709 domain-containing protein | - |
| EPB59_RS18115 | 1047036..1047296 | + | 261 | WP_195707179.1 | DUF3709 domain-containing protein | - |
| EPB59_RS18120 | 1047546..1047845 | - | 300 | WP_000802134.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| EPB59_RS18125 | 1047842..1048084 | - | 243 | WP_001107720.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| EPB59_RS18130 | 1048452..1048631 | + | 180 | WP_114732530.1 | DUF645 family protein | - |
| EPB59_RS18135 | 1048895..1049284 | + | 390 | WP_195707144.1 | VOC family protein | - |
| EPB59_RS18140 | 1049481..1049804 | + | 324 | WP_154174224.1 | DUF3709 domain-containing protein | - |
| EPB59_RS18145 | 1049996..1050211 | + | 216 | WP_154174194.1 | DUF3709 domain-containing protein | - |
| EPB59_RS18150 | 1050223..1050354 | + | 132 | WP_001886409.1 | DUF3709 domain-containing protein | - |
| EPB59_RS18155 | 1050367..1050441 | + | 75 | WP_108244119.1 | hypothetical protein | - |
| EPB59_RS18170 | 1051098..1051613 | + | 516 | WP_154173275.1 | lipocalin family protein | - |
| EPB59_RS18175 | 1051712..1051873 | + | 162 | Protein_957 | DUF3709 domain-containing protein | - |
| EPB59_RS18180 | 1051867..1052127 | + | 261 | WP_195707179.1 | DUF3709 domain-containing protein | - |
| EPB59_RS18185 | 1052555..1052734 | + | 180 | WP_114732530.1 | DUF645 family protein | - |
| EPB59_RS18190 | 1052860..1053044 | + | 185 | Protein_960 | DUF3709 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | cqsA / ugd / hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA | 3..1074150 | 1074147 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11601.34 Da Isoelectric Point: 9.9232
>T118257 WP_000802134.1 NZ_CP035687:c1047845-1047546 [Vibrio metoecus]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQIGSQQ
IRVIRILHKSMDVNPIFGA
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQIGSQQ
IRVIRILHKSMDVNPIFGA
Download Length: 300 bp
>T118257 NZ_CP035687:c1047845-1047546 [Vibrio metoecus]
ATGAAACCATTTAATCTTACTGTCGCCGCTAAAGCCGATTTACGGGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATCGGTAAATCAT
GCGATGAAATTCGAGAGGGATACAGAAAATTTCCCCAAGGGAGCCACGTCATCTTTTATCAGCAAATCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTTGGCGCATAA
ATGAAACCATTTAATCTTACTGTCGCCGCTAAAGCCGATTTACGGGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATCGGTAAATCAT
GCGATGAAATTCGAGAGGGATACAGAAAATTTCCCCAAGGGAGCCACGTCATCTTTTATCAGCAAATCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTTGGCGCATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8950.82 Da Isoelectric Point: 4.1677
>AT118257 WP_001107720.1 NZ_CP035687:c1048084-1047842 [Vibrio metoecus]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR
Download Length: 243 bp
>AT118257 NZ_CP035687:c1048084-1047842 [Vibrio metoecus]
ATGGCTAAAAACACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGACGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAATTAC
TTGTTGAAGGTGAGCAAAGTGGTGATGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA
ATGGCTAAAAACACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGACGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAATTAC
TTGTTGAAGGTGAGCAAAGTGGTGATGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|