Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /BrnT(toxin) |
| Location | 1041159..1041657 | Replicon | chromosome |
| Accession | NZ_CP035687 | ||
| Organism | Vibrio metoecus strain 2011V-1169 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | Q9KMK7 |
| Locus tag | EPB59_RS18035 | Protein ID | WP_000589156.1 |
| Coordinates | 1041159..1041425 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | EPB59_RS18040 | Protein ID | WP_088900031.1 |
| Coordinates | 1041412..1041657 (+) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EPB59_RS17980 | 1036332..1036814 | + | 483 | WP_154174184.1 | GNAT family N-acetyltransferase | - |
| EPB59_RS17990 | 1037112..1037291 | + | 180 | Protein_924 | DUF645 family protein | - |
| EPB59_RS17995 | 1037440..1037600 | + | 161 | Protein_925 | DUF3709 domain-containing protein | - |
| EPB59_RS18000 | 1037621..1037842 | + | 222 | Protein_926 | DUF3709 domain-containing protein | - |
| EPB59_RS18010 | 1038688..1039011 | + | 324 | WP_025633656.1 | DUF4144 domain-containing protein | - |
| EPB59_RS18015 | 1039046..1039135 | + | 90 | WP_154174189.1 | DUF3265 domain-containing protein | - |
| EPB59_RS18020 | 1039309..1039490 | + | 182 | Protein_929 | DUF645 family protein | - |
| EPB59_RS18025 | 1039688..1040092 | + | 405 | WP_154174191.1 | DUF1801 domain-containing protein | - |
| EPB59_RS18480 | 1041032..1041103 | + | 72 | WP_114983889.1 | hypothetical protein | - |
| EPB59_RS18035 | 1041159..1041425 | + | 267 | WP_000589156.1 | BrnT family toxin | Toxin |
| EPB59_RS18040 | 1041412..1041657 | + | 246 | WP_088900031.1 | CopG family transcriptional regulator | Antitoxin |
| EPB59_RS18045 | 1041820..1042188 | + | 369 | WP_026050325.1 | VOC family protein | - |
| EPB59_RS18050 | 1042370..1042891 | + | 522 | WP_154174192.1 | hypothetical protein | - |
| EPB59_RS18055 | 1043181..1043624 | + | 444 | WP_154174221.1 | hypothetical protein | - |
| EPB59_RS18065 | 1043772..1044239 | + | 468 | WP_000702485.1 | GNAT family N-acetyltransferase | - |
| EPB59_RS18070 | 1044329..1044516 | + | 188 | Protein_938 | DUF3709 domain-containing protein | - |
| EPB59_RS18075 | 1044513..1044688 | + | 176 | Protein_939 | DUF3709 domain-containing protein | - |
| EPB59_RS18080 | 1045175..1045354 | + | 180 | WP_029628718.1 | DUF645 family protein | - |
| EPB59_RS18085 | 1045531..1045848 | - | 318 | WP_000077449.1 | CcdB family protein | - |
| EPB59_RS18090 | 1045848..1046093 | - | 246 | WP_001260801.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| EPB59_RS18095 | 1046214..1046429 | + | 216 | WP_154173277.1 | DUF3709 domain-containing protein | - |
| EPB59_RS18100 | 1046441..1046572 | + | 132 | WP_001886409.1 | DUF3709 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | cqsA / ugd / hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA | 3..1074150 | 1074147 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10092.34 Da Isoelectric Point: 7.3171
>T118256 WP_000589156.1 NZ_CP035687:1041159-1041425 [Vibrio metoecus]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA
Download Length: 267 bp
>T118256 NZ_CP035687:1041159-1041425 [Vibrio metoecus]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
GTTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
GTTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9492.79 Da Isoelectric Point: 6.4838
>AT118256 WP_088900031.1 NZ_CP035687:1041412-1041657 [Vibrio metoecus]
MKAHEFDAKFESDDDEIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R
MKAHEFDAKFESDDDEIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R
Download Length: 246 bp
>AT118256 NZ_CP035687:1041412-1041657 [Vibrio metoecus]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGAGATCGTAATGGACTTGGATCTATCACAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GAATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTTGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGAGATCGTAATGGACTTGGATCTATCACAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GAATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTTGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|