Detailed information of TA system TA118255

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-Phd
• Location: 50391..50938
• Replicon: chromosome
• Accession: NZ_CP035687
• Organism: Vibrio metoecus strain 2011V-1169

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EPB59_RS13765
• Protein ID: WP_095484351.1
• Coordinates: 50636..50938 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9KM93
• Locus tag: EPB59_RS13760
• Protein ID: WP_000861987.1
• Coordinates: 50391..50648 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EPB59_RS13725	45625..46305	+	681	WP_154173304.1	hypothetical protein	-
EPB59_RS13730	46441..46866	+	426	WP_154173306.1	GNAT family N-acetyltransferase	-
EPB59_RS13735	47009..47542	+	534	WP_002053700.1	GNAT family N-acetyltransferase	-
EPB59_RS18460	47837..48044	+	208	Protein_85	DUF645 family protein	-
EPB59_RS13750	48229..49248	+	1020	WP_138040483.1	putative phage abortive infection protein	-
EPB59_RS13755	49391..50182	+	792	WP_172858851.1	PhzF family phenazine biosynthesis protein	-
EPB59_RS13760	50391..50648	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EPB59_RS13765	50636..50938	+	303	WP_095484351.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EPB59_RS13775	51271..51424	+	154	Protein_90	DUF645 family protein	-
EPB59_RS13780	51777..51923	+	147	Protein_91	DUF645 family protein	-
EPB59_RS13785	52262..52531	+	270	WP_154173311.1	hypothetical protein	-
EPB59_RS18465	52719..52946	+	228	WP_195707152.1	hypothetical protein	-
EPB59_RS13790	53094..53627	+	534	WP_154173313.1	cysteine hydrolase	-
EPB59_RS13795	53690..53785	+	96	WP_095475369.1	acetyltransferase	-
EPB59_RS13800	53817..54230	+	414	WP_154173315.1	VOC family protein	-
EPB59_RS13805	54400..55497	+	1098	WP_154173317.1	hypothetical protein	-
EPB59_RS13810	55490..55603	+	114	WP_080933796.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	cqsA / ugd / hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA	3..1074150	1074147

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11765.72 Da
• Isoelectric Point: 5.1972

>T118255 WP_095484351.1 NZ_CP035687:50636-50938 [Vibrio metoecus]
MVEIIWTEPALSDLNDIVEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T118255 NZ_CP035687:50636-50938 [Vibrio metoecus]
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGACCTGAATGATATTGTTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTTCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAATCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9647.15 Da
• Isoelectric Point: 7.3178

>AT118255 WP_000861987.1 NZ_CP035687:50391-50648 [Vibrio metoecus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Nucleotide

• Length: 258 bp

>AT118255 NZ_CP035687:50391-50648 [Vibrio metoecus]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATTCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A1T4SLM9