Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 25955..26493 | Replicon | chromosome |
| Accession | NZ_CP035687 | ||
| Organism | Vibrio metoecus strain 2011V-1169 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | EPB59_RS13555 | Protein ID | WP_000802134.1 |
| Coordinates | 25955..26254 (-) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A271VK51 |
| Locus tag | EPB59_RS13560 | Protein ID | WP_001107720.1 |
| Coordinates | 26251..26493 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EPB59_RS13485 | 21035..21319 | - | 285 | WP_000381186.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| EPB59_RS13490 | 21514..22029 | + | 516 | WP_154173275.1 | lipocalin family protein | - |
| EPB59_RS13495 | 22155..22472 | - | 318 | WP_000077449.1 | CcdB family protein | - |
| EPB59_RS13500 | 22472..22717 | - | 246 | WP_001260801.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| EPB59_RS13505 | 22838..23053 | + | 216 | WP_154173277.1 | DUF3709 domain-containing protein | - |
| EPB59_RS13510 | 23065..23196 | + | 132 | WP_001886409.1 | DUF3709 domain-containing protein | - |
| EPB59_RS13515 | 23209..23283 | + | 75 | WP_108244119.1 | hypothetical protein | - |
| EPB59_RS18455 | 23766..23861 | + | 96 | WP_001907607.1 | DUF645 family protein | - |
| EPB59_RS13525 | 24011..24172 | + | 162 | Protein_45 | DUF3709 domain-containing protein | - |
| EPB59_RS13530 | 24166..24426 | + | 261 | WP_195707179.1 | DUF3709 domain-containing protein | - |
| EPB59_RS13535 | 24649..24836 | + | 188 | Protein_47 | DUF3709 domain-containing protein | - |
| EPB59_RS13540 | 24833..25008 | + | 176 | Protein_48 | DUF3709 domain-containing protein | - |
| EPB59_RS13545 | 25288..25451 | + | 164 | Protein_49 | DUF3709 domain-containing protein | - |
| EPB59_RS13550 | 25445..25705 | + | 261 | WP_195707179.1 | DUF3709 domain-containing protein | - |
| EPB59_RS13555 | 25955..26254 | - | 300 | WP_000802134.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| EPB59_RS13560 | 26251..26493 | - | 243 | WP_001107720.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| EPB59_RS13565 | 26863..27042 | + | 180 | WP_029628718.1 | DUF645 family protein | - |
| EPB59_RS13570 | 27284..27607 | + | 324 | WP_154174224.1 | DUF3709 domain-containing protein | - |
| EPB59_RS13575 | 27874..28389 | + | 516 | WP_000343786.1 | GNAT family N-acetyltransferase | - |
| EPB59_RS13580 | 28545..29699 | + | 1155 | WP_154173281.1 | DUF3800 domain-containing protein | - |
| EPB59_RS13585 | 29696..29806 | + | 111 | WP_154174226.1 | DUF3265 domain-containing protein | - |
| EPB59_RS13590 | 29871..30107 | - | 237 | WP_154173282.1 | RNA-binding protein | - |
| EPB59_RS13595 | 30372..30839 | + | 468 | WP_000702485.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | cqsA / ugd / hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA | 3..1074150 | 1074147 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11601.34 Da Isoelectric Point: 9.9232
>T118254 WP_000802134.1 NZ_CP035687:c26254-25955 [Vibrio metoecus]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQIGSQQ
IRVIRILHKSMDVNPIFGA
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQIGSQQ
IRVIRILHKSMDVNPIFGA
Download Length: 300 bp
>T118254 NZ_CP035687:c26254-25955 [Vibrio metoecus]
ATGAAACCATTTAATCTTACTGTCGCCGCTAAAGCCGATTTACGGGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATCGGTAAATCAT
GCGATGAAATTCGAGAGGGATACAGAAAATTTCCCCAAGGGAGCCACGTCATCTTTTATCAGCAAATCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTTGGCGCATAA
ATGAAACCATTTAATCTTACTGTCGCCGCTAAAGCCGATTTACGGGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATCGGTAAATCAT
GCGATGAAATTCGAGAGGGATACAGAAAATTTCCCCAAGGGAGCCACGTCATCTTTTATCAGCAAATCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTTGGCGCATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8950.82 Da Isoelectric Point: 4.1677
>AT118254 WP_001107720.1 NZ_CP035687:c26493-26251 [Vibrio metoecus]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR
Download Length: 243 bp
>AT118254 NZ_CP035687:c26493-26251 [Vibrio metoecus]
ATGGCTAAAAACACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGACGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAATTAC
TTGTTGAAGGTGAGCAAAGTGGTGATGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA
ATGGCTAAAAACACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGACGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAATTAC
TTGTTGAAGGTGAGCAAAGTGGTGATGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|