Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 20760..21319 | Replicon | chromosome |
| Accession | NZ_CP035687 | ||
| Organism | Vibrio metoecus strain 2011V-1169 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D2YI11 |
| Locus tag | EPB59_RS13480 | Protein ID | WP_000578473.1 |
| Coordinates | 20760..21038 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | EPB59_RS13485 | Protein ID | WP_000381186.1 |
| Coordinates | 21035..21319 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EPB59_RS13445 | 16149..16274 | + | 126 | WP_119773660.1 | DUF3265 domain-containing protein | - |
| EPB59_RS18445 | 16311..16916 | + | 606 | WP_114967336.1 | hypothetical protein | - |
| EPB59_RS13450 | 17220..17391 | + | 172 | Protein_29 | DUF645 family protein | - |
| EPB59_RS13455 | 17600..18136 | + | 537 | WP_042989109.1 | GNAT family N-acetyltransferase | - |
| EPB59_RS18450 | 18193..18309 | + | 117 | WP_195707150.1 | iron transporter | - |
| EPB59_RS13460 | 18272..18778 | + | 507 | WP_000393074.1 | hypothetical protein | - |
| EPB59_RS13465 | 18991..19380 | + | 390 | WP_195707144.1 | VOC family protein | - |
| EPB59_RS13470 | 19690..19869 | + | 180 | WP_114732530.1 | DUF645 family protein | - |
| EPB59_RS13475 | 20178..20621 | + | 444 | WP_154174221.1 | hypothetical protein | - |
| EPB59_RS13480 | 20760..21038 | - | 279 | WP_000578473.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| EPB59_RS13485 | 21035..21319 | - | 285 | WP_000381186.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| EPB59_RS13490 | 21514..22029 | + | 516 | WP_154173275.1 | lipocalin family protein | - |
| EPB59_RS13495 | 22155..22472 | - | 318 | WP_000077449.1 | CcdB family protein | - |
| EPB59_RS13500 | 22472..22717 | - | 246 | WP_001260801.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| EPB59_RS13505 | 22838..23053 | + | 216 | WP_154173277.1 | DUF3709 domain-containing protein | - |
| EPB59_RS13510 | 23065..23196 | + | 132 | WP_001886409.1 | DUF3709 domain-containing protein | - |
| EPB59_RS13515 | 23209..23283 | + | 75 | WP_108244119.1 | hypothetical protein | - |
| EPB59_RS18455 | 23766..23861 | + | 96 | WP_001907607.1 | DUF645 family protein | - |
| EPB59_RS13525 | 24011..24172 | + | 162 | Protein_45 | DUF3709 domain-containing protein | - |
| EPB59_RS13530 | 24166..24426 | + | 261 | WP_195707179.1 | DUF3709 domain-containing protein | - |
| EPB59_RS13535 | 24649..24836 | + | 188 | Protein_47 | DUF3709 domain-containing protein | - |
| EPB59_RS13540 | 24833..25008 | + | 176 | Protein_48 | DUF3709 domain-containing protein | - |
| EPB59_RS13545 | 25288..25451 | + | 164 | Protein_49 | DUF3709 domain-containing protein | - |
| EPB59_RS13550 | 25445..25705 | + | 261 | WP_195707179.1 | DUF3709 domain-containing protein | - |
| EPB59_RS13555 | 25955..26254 | - | 300 | WP_000802134.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | cqsA / ugd / hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA | 3..1074150 | 1074147 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10868.59 Da Isoelectric Point: 4.6794
>T118253 WP_000578473.1 NZ_CP035687:c21038-20760 [Vibrio metoecus]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIETKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIETKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T118253 NZ_CP035687:c21038-20760 [Vibrio metoecus]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTTTACGACTTTAACCCAGCAGCCGC
TGAAAAAACGGATGAGCTCATAGAAACCAAAGTCGAAAATTTGCTTGAGCAACCACTAATGGGGGTTCAGCGTGATGGTA
TTCGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTTTACGACTTTAACCCAGCAGCCGC
TGAAAAAACGGATGAGCTCATAGAAACCAAAGTCGAAAATTTGCTTGAGCAACCACTAATGGGGGTTCAGCGTGATGGTA
TTCGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10915.28 Da Isoelectric Point: 8.0775
>AT118253 WP_000381186.1 NZ_CP035687:c21319-21035 [Vibrio metoecus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFVEHDIAKVR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFVEHDIAKVR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT118253 NZ_CP035687:c21319-21035 [Vibrio metoecus]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGGAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAACAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCGGTATTCGTTGAACATGACATCGCCAAAGTGCGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGTCACGCATGA
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGGAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAACAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCGGTATTCGTTGAACATGACATCGCCAAAGTGCGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGTCACGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|