Detailed information of TA system TA118252

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-Phd
• Location: 208553..209131
• Replicon: chromosome
• Accession: NZ_CP035683
• Organism: Vibrio mimicus strain 2011V-1073

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: ET951_RS15910
• Protein ID: WP_059261326.1
• Coordinates: 208553..208870 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: ET951_RS15915
• Protein ID: WP_148546882.1
• Coordinates: 208889..209131 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ET951_RS15860	204037..204222	+	186	Protein_285	disulfide bond formation protein DsbD	-
ET951_RS15865	204216..204440	+	225	WP_192927736.1	DUF3709 domain-containing protein	-
ET951_RS15875	204837..205289	+	453	WP_154114460.1	GNAT family N-acetyltransferase	-
ET951_RS15880	205584..205765	+	182	Protein_288	DUF645 family protein	-
ET951_RS15885	205963..206241	-	279	WP_154113949.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ET951_RS15890	206238..206522	-	285	WP_000381185.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
ET951_RS15895	206780..207028	+	249	WP_154113950.1	hypothetical protein	-
ET951_RS15900	207347..207528	+	182	Protein_292	DUF645 family protein	-
ET951_RS15905	208180..208397	+	218	Protein_293	DUF645 family protein	-
ET951_RS15910	208553..208870	-	318	WP_059261326.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ET951_RS15915	208889..209131	-	243	WP_148546882.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ET951_RS15920	209404..209624	+	221	Protein_296	DUF1289 domain-containing protein	-
ET951_RS15940	210148..211056	-	909	WP_154113953.1	LysR family transcriptional regulator	-
ET951_RS15945	211152..212396	+	1245	WP_154113954.1	MFS transporter	-
ET951_RS15950	212495..213046	-	552	WP_154113955.1	TetR/AcrR family transcriptional regulator	-
ET951_RS15955	213144..213596	+	453	WP_001089479.1	HPP family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	54396..217049	162653
	-	inside	Integron	-	-	55591..210101	154510

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12194.02 Da
• Isoelectric Point: 9.5547

>T118252 WP_059261326.1 NZ_CP035683:c208870-208553 [Vibrio mimicus]
MQNKQYKLSQLAQEHLLKIRNYTIENFAQAQWLKYKSTLLSGFQTLADNPELGKSCEDIYKNGFYFPVGKHMAYYTKEAD
FILIVAVLGQSQLPQKHLTQSRFVS

Nucleotide

• Length: 318 bp

>T118252 NZ_CP035683:c208870-208553 [Vibrio mimicus]
ATGCAAAACAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAGAAACTACACCATTGAAAATTT
CGCTCAAGCACAATGGCTAAAATATAAATCGACCTTGCTTTCAGGTTTCCAGACTCTAGCGGATAATCCAGAGCTAGGAA
AAAGCTGTGAAGATATTTACAAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAGAC
TTCATTCTCATCGTCGCTGTATTAGGGCAATCACAGCTGCCCCAGAAACATCTCACACAGTCACGTTTCGTTTCTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9028.34 Da
• Isoelectric Point: 5.0491

>AT118252 WP_148546882.1 NZ_CP035683:c209131-208889 [Vibrio mimicus]
MYTLTANDAKRNFGELLLSAQREPIIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDNGKTVDGATFLNTL

Nucleotide

• Length: 243 bp

>AT118252 NZ_CP035683:c209131-208889 [Vibrio mimicus]
ATGTACACACTAACAGCAAATGATGCTAAACGAAATTTTGGAGAACTTCTTCTAAGCGCACAGCGCGAGCCTATCATAAT
CAGCAAAAACAGTAAAAATACTGTCGTTGTCATGTCCATTAAGGATTTTGAAGAGCTTGAAGCCATGAAACTCGATTATC
TTAAACACTGCTTTGAGTCCGCTCAGAAAGACTTAGATAATGGCAAAACCGTTGATGGTGCTACTTTTCTAAACACCCTT
TGA