Detailed information of TA system TA118251

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 205963..206522
• Replicon: chromosome
• Accession: NZ_CP035683
• Organism: Vibrio mimicus strain 2011V-1073

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ET951_RS15885
• Protein ID: WP_154113949.1
• Coordinates: 205963..206241 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0N8UHC9
• Locus tag: ET951_RS15890
• Protein ID: WP_000381185.1
• Coordinates: 206238..206522 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ET951_RS15850	202269..202724	+	456	WP_154113946.1	hypothetical protein	-
ET951_RS15855	203184..203957	+	774	WP_154113947.1	NERD domain-containing protein	-
ET951_RS15860	204037..204222	+	186	Protein_285	disulfide bond formation protein DsbD	-
ET951_RS15865	204216..204440	+	225	WP_192927736.1	DUF3709 domain-containing protein	-
ET951_RS15875	204837..205289	+	453	WP_154114460.1	GNAT family N-acetyltransferase	-
ET951_RS15880	205584..205765	+	182	Protein_288	DUF645 family protein	-
ET951_RS15885	205963..206241	-	279	WP_154113949.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ET951_RS15890	206238..206522	-	285	WP_000381185.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
ET951_RS15895	206780..207028	+	249	WP_154113950.1	hypothetical protein	-
ET951_RS15900	207347..207528	+	182	Protein_292	DUF645 family protein	-
ET951_RS15905	208180..208397	+	218	Protein_293	DUF645 family protein	-
ET951_RS15910	208553..208870	-	318	WP_059261326.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ET951_RS15915	208889..209131	-	243	WP_148546882.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
ET951_RS15920	209404..209624	+	221	Protein_296	DUF1289 domain-containing protein	-
ET951_RS15940	210148..211056	-	909	WP_154113953.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	54396..217049	162653
	-	inside	Integron	-	-	55591..210101	154510

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10825.56 Da
• Isoelectric Point: 5.1425

>T118251 WP_154113949.1 NZ_CP035683:c206241-205963 [Vibrio mimicus]
MIFWEEASLNDRVKTFEFLYDFNPAAAEKTDELIETKVENLLEQPLMGVQRNGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Nucleotide

• Length: 279 bp

>T118251 NZ_CP035683:c206241-205963 [Vibrio mimicus]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGAGTGAAAACTTTCGAATTTCTTTACGACTTTAACCCAGCGGCCGC
TGAAAAAACGGATGAGCTCATAGAAACCAAAGTTGAAAATTTGCTTGAGCAACCACTAATGGGTGTTCAGCGTAATGGCA
TTCGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10887.22 Da
• Isoelectric Point: 8.0775

>AT118251 WP_000381185.1 NZ_CP035683:c206522-206238 [Vibrio mimicus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFVEHDIAKAR
MAERKAKIRNRGHA

Nucleotide

• Length: 285 bp

>AT118251 NZ_CP035683:c206522-206238 [Vibrio mimicus]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCGGTATTCGTTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGTCACGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A0N8UHC9