Detailed information of TA system TA118249

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 161790..162318
• Replicon: chromosome
• Accession: NZ_CP035683
• Organism: Vibrio mimicus strain 2011V-1073

Toxin (Protein)

• Gene name: relE
• Uniprot ID: H9L4R3
• Locus tag: ET951_RS15505
• Protein ID: WP_000221352.1
• Coordinates: 161790..162080 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: H9L4T4
• Locus tag: ET951_RS15510
• Protein ID: WP_000213183.1
• Coordinates: 162070..162318 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ET951_RS15465	157206..157670	+	465	WP_154113909.1	N-acetyltransferase	-
ET951_RS15470	158409..158591	+	183	WP_154113910.1	DUF645 family protein	-
ET951_RS15480	158810..159223	+	414	WP_154113911.1	GNAT family N-acetyltransferase	-
ET951_RS15485	159380..160174	+	795	WP_154113912.1	phospholipase D family protein	-
ET951_RS15490	160319..160696	+	378	WP_148535404.1	hypothetical protein	-
ET951_RS15495	160849..161207	+	359	Protein_217	VOC family protein	-
ET951_RS15500	161380..161652	+	273	WP_154113913.1	antibiotic biosynthesis monooxygenase	-
ET951_RS15505	161790..162080	-	291	WP_000221352.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ET951_RS15510	162070..162318	-	249	WP_000213183.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ET951_RS15515	162504..162890	+	387	WP_033197487.1	VOC family protein	-
ET951_RS15520	163035..164384	+	1350	WP_154113914.1	hypothetical protein	-
ET951_RS15525	164621..164857	+	237	WP_154113915.1	DUF645 family protein	-
ET951_RS15535	165058..165468	+	411	WP_000452032.1	hypothetical protein	-
ET951_RS15540	165562..165987	+	426	WP_154113917.1	GNAT family N-acetyltransferase	-
ET951_RS15545	166141..166677	+	537	WP_154113918.1	GNAT family N-acetyltransferase	-
ET951_RS15550	166818..167222	+	405	WP_154113919.1	GFA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	54396..217049	162653
	-	inside	Integron	-	-	55591..210101	154510

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11247.23 Da
• Isoelectric Point: 10.4678

>T118249 WP_000221352.1 NZ_CP035683:c162080-161790 [Vibrio mimicus]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Nucleotide

• Length: 291 bp

>T118249 NZ_CP035683:c162080-161790 [Vibrio mimicus]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8937.28 Da
• Isoelectric Point: 4.1079

>AT118249 WP_000213183.1 NZ_CP035683:c162318-162070 [Vibrio mimicus]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Nucleotide

• Length: 249 bp

>AT118249 NZ_CP035683:c162318-162070 [Vibrio mimicus]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGCGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCAGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Structures

Toxin

• AlphaFold DB: H9L4R3

Antitoxin

• AlphaFold DB: A0A366A3W8